This movie shows how trans-endocytosis of Notch into Delta expressing cells contributes to Notch activation. N-ECD represents the Notch extracellular domain, N-ICD represents Notch intracellular domain, {delta} represents the Delta ligand. Animation created by BioCreations.

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Citation: H. Krämer, RIPping Notch Apart: A New Role for Endocytosis in Signal Transduction? Science's STKE (2000),;2000/29/pe1

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