Domains Articles III

A Series on Protein Domains in Signal Transduction

16 December 2003

Lipid-Binding Structures 16 December 03

Reviews
Perspectives
  • Finding Partners: Emerging Protein Interaction Technologies Applied to Signaling Networks

    Igor Stagljar

    SILAC, TAIS, domain profiling, and mbYTH are new methods for revealing protein partners. [Summary] [Full Text] [PDF]

18 November 2003

Structures in Signaling 18 November 03

Reviews
  • Organization and Functions of Interacting Domains for Signaling by Protein-Protein Interactions

    Elizabeth Buck and Ravi Iyengar

    Division of labor in protein interaction domains appears to separate binding from actual signal transfer. [Gloss] [Abstract] [Full Text] [PDF]

15 July 2003

Structures in Signaling 15 July 03

Reviews
  • SH2 and PTB Domains in Tyrosine Kinase Signaling

    Joseph Schlessinger and Mark A. Lemmon

    Motifs that recognize phosphorylated tyrosines are essential regulators of cellular signaling events. [Gloss] [Abstract] [Full Text] [PDF]
Perspectives
  • A Kelch β-Propeller Featuring as a Gβ Structural Mimic: Reinventing the Wheel?

    Jan Gettemans, Kris Meerschaert, Joël Vandekerckhove, and Veerle De Corte

    Structural similarity may allow proteins with diverse primary sequences to serve in the G protein heterotrimer. [Summary] [Full Text] [PDF]
Teaching Resources
  • Activation of Ras by Grb2-SOS: Demonstrating an Assembly Role of SH3 Domains

    Ali Zarrinpar, Roby P. Bhattacharyya, Wendell A. Lim, and Nancy R. Gough

    A simple animation showing how SH3 domains participate in mitogen-activated protein kinase signaling. [Summary] [Resource]

22 April 2003

Structures in Signaling 22 April 03

Reviews
  • Gene Regulation at the RNA Layer: RNA-Binding Proteins in Intercellular Signaling Networks

    Paul Lasko

    How extracellular signals can regulate RNA processing, transport, and translation to control gene expression. [Gloss] [Abstract] [Full Text] [PDF]
  • PDZ Domain Proteins: Plug and Play!

    Claire Nourry, Seth G. N. Grant, and Jean-Paul Borg

    PDZ domains provide the scaffold for functional complexes implicated in health and disease in polar cells. [Gloss] [Abstract] [Full Text] [PDF]
  • The Structure and Function of Proline Recognition Domains

    Ali Zarrinpar, Roby P. Bhattacharyya, and Wendell A. Lim

    Understanding the structural basis of a commonly used motif present in many proteins involved in signal transduction.[Gloss] [Abstract] [Full Text] [PDF] [Structures]