Protein Kinases
(PowerPoint Slides)

Avrom J. Caplan*

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.


*Corresponding author. E-mail: avrom.caplan{at}


These slides are designed for a class covering the structure and function of protein kinases and is part of the course �Cell Signaling Systems: A Course for Graduate Students.� The lecture begins with a discussion of the genomics and evolutionary relationships among kinases and then proceeds to describe the structure-function relationships of specific kinases, the molecular mechanisms underlying substrate specificity, and selected issues in regulation of kinase activity.

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Educational Details

Learning Resource Type: PowerPoint slides

Context: Undergraduate upper division, graduate, professional (degree program)

Intended Users: Teacher, learner

Intended Educational Use: Teach, learn

Discipline: Cell biology, biochemistry, structural biology, and bioinformatics genomics & proteomics

Keywords: structure-function relationships, substrate specificity, protein kinase A, tyrosine kinase, MAP kinase, regulation by phosphorylation, P-loop, chemotherapy

Technical Details

Format: PowerPoint

Size: 13.5 MB

Requirements: Microsoft PowerPoint

Limits for Use

Cost: Free

Rights: This material may be downloaded for noncommercial, course-teaching purposes only, provided credit to STKE is included by listing the citation for the Teaching Resource.


Citation: A. J. Caplan, Protein kinases. Sci. STKE2005, tr7 (2005).

© 2005 American Association for the Advancement of Science