Protein Phosphatases
(PowerPoint Slides)

Stephen R. Salton*

Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA.


*Contact information. E-mail: stephen.salton{at}


These slides are designed for a class covering the structure and function of protein phosphatases and are part of the course "Cell Signaling Systems: A Course for Graduate Students". The lecture begins with a discussion of the importance of phosphatases in physiology recognized by the award of a Nobel Prize in 1992 and then proceeds to describe the two types of protein phosphatases: serine/threonine and tyrosine phosphatases. The information covered includes the structure, regulation, and substrate specificity of protein phosphatases, with an emphasis on their importance in disease and clinical settings.

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Educational Details

Learning Resource Type: PowerPoint slides

Context: Undergraduate upper division, graduate, professional (degree program)

Intended Users: Teacher, learner

Intended Educational Use: Teach, learn

Discipline: Cell biology, biochemistry, immunology, pharmacology, and structural biology

Keywords: Phosphatases, dephosphorylation, PTP, PP2A, signal transduction, immune suppression

Technical Details

Format: PowerPoint

Size: 4.8 MB

Requirements: Microsoft PowerPoint

Limits for Use

Cost: Free

Rights: This material may be downloaded for noncommercial, course-teaching purposes only, provided credit to STKE is included by listing the citation for the teaching resource.


Citation: S. R. Salton, Protein phosphatases. Sci. STKE 2005, tr8 (2005).

© 2005 American Association for the Advancement of Science