Protein Domains that Interact with Receptor Tyrosine Kinases:

Structural Aspects

(PowerPoint Slides)

Ming-Ming Zhou*

Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, NY 10029, USA.


*Contact information. E-mail: ming-ming.zhou{at}; Web site:


These slides are intended for a class covering insights gained from structural analysis of the regulation of receptor tyrosine kinases and is part of the course �Cell Signaling Systems: A Course for Graduate Students�. The lecture begins with an overview of the many protein domains thus far implicated in cell signaling and then describes in detail the phosphotyrosine-binding domain (PTB). The application of structural information to rational drug design by targeting protein interaction domains is also covered.

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Educational Details

Learning Resource Type: PowerPoint slides

Context: Undergraduate upper division, graduate, professional (degree program)

Intended Users: Teacher, learner

Intended Educational Use: Teach, learn, plan

Discipline: Molecular biology, cell biology, biochemistry, structural biology, pharmacology

Keywords: SH2 domain, PTB domain, protein structure, signal transduction

Technical Details

Format: PowerPoint

Size: 10.4 MB

Requirements: Microsoft PowerPoint

Limits for Use

Cost: Free

Rights: This material may be downloaded for noncommercial, course-teaching purposes only, provided credit to STKE is included by listing the citation for the Teaching Resource.


Citation: M.-M. Zhou, Protein domains that interact with receptor tyrosine kinases: Structural aspects. Sci. STKE2005, tr9 (2005).

© 2005 American Association for the Advancement of Science