G Protein-Coupled Receptors
(PowerPoint Slides)

Stuart C. Sealfon*

Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA.


*Contact information. E-mail: stuart.sealfon{at}


Slides are provided for a class covering G protein-coupled receptors (GPCRs) and are part of the course �Cell Signaling Systems: A Course for Graduate Students.� The slides begin with a discussion of the major classes of GPCRs and then proceed to describe the mechanisms of receptor diversity, ligand interaction, desensitization, coupling, and mutations associated with human diseases.

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Educational Details

Learning Resource Type: PowerPoint slides

Context: Undergraduate upper division, graduate, professional (degree program)

Intended Users: Teacher, learner

Intended Educational Use: Teach, learn, plan

Discipline: Biochemistry, Molecular Biology, Pharmacology, Structural Biology, Genetics, Cell Biology

Keywords: G protein-coupled receptors, rhodopsin structure, GPCR kinases (GRKs), desensitization, dimerization

Technical Details

Format: PowerPoint (ppt)

Size: 983 KB

Requirements: Microsoft PowerPoint

Limits for Use

Cost: Free

Rights: This material may be downloaded for noncommercial, course-teaching purposes only, provided credit to STKE is included by listing the citation for the Teaching Resource.


Citation: S.C. Sealfon, G protein�coupled receptors. Sci. STKE2005, tr11 (2005).

© 2005 American Association for the Advancement of Science