Proteases and Signaling
(PowerPoint Slides)

Sherwin Wilk*

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.


*Contact information. E-mail, sherwin.wilk{at}


Slides are provided for a class covering the role of proteolysis in signal transduction and are part of the course "Cell Signaling Systems: A Course for Graduate Students." The slides begin with a discussion of protease-activated receptors and then proceed to describe the ubiquitin-proteasome system and some of the ways that proteolysis can function in signal transduction.

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Educational Details

Learning Resource Type: PowerPoint slides

Context: Undergraduate upper division, graduate, professional (degree program)

Intended Users: Teacher, learner

Intended Educational Use: Teach, learn, plan

Discipline: Biochemistry, Molecular Biology, Pharmacology, Structural Biology, Cell Biology, Microbiology

Keywords: proteolysis, ubiquitin, proteasome, regulated intramembrane proteolysis, thrombin, presenilin, MAPK

Technical Details

Format: PowerPoint (ppt)

Size: 6.19 MB

Requirements: Microsoft PowerPoint

Limits for Use

Cost: Free

Rights: This material may be downloaded for noncommercial, course-teaching purposes only, provided credit to STKE is included by listing the citation for the Teaching Resource.


Citation: S. Wilk, Proteases and signaling. Sci. STKE2005, tr15 (2005).

© 2005 American Association for the Advancement of Science