Nuclear Transactivators and Repressors
(PowerPoint Slides)

Zhen-Qiang Pan*

Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.


*Contact information. E-mail: zhen-qiang.pan{at}


Slides are provided for a class covering the mechanism and regulation of eukaryotic gene transcription machinery and are part of the course �Cell Signaling Systems: A Course for Graduate Students.� The slides begin with an overview of eukaryotic gene transcription and then proceed to describe mechanisms of transcription by RNA polymerase II, the action of Mediator, and enhancer-promoter communication during gene activation.

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Educational Details

Learning Resource Type: PowerPoint slides

Context: Undergraduate upper division, graduate, professional (degree program)

Intended Users: Teacher, learner

Intended Educational Use: Teach, learn, plan

Discipline: Biochemistry, Molecular Biology, Structural Biology

Keywords: eukaryotic gene transcription, RNA Polymerase II, Mediator, TFII (transcription factor for polymerase II)

Technical Details

Format: PowerPoint (ppt)

Size: 2.3 MB

Requirements: Microsoft PowerPoint

Limits for Use

Cost: Free

Rights: This material may be downloaded for noncommercial, course-teaching purposes only, provided credit to STKE is included by listing the citation for the Teaching Resource.


Citation: Z.Q. Pan, Nuclear transactivators and repressors. Sci. STKE2005, tr18 (2005).

© 2005 American Association for the Advancement of Science