Long-Term Potentiation: Mechanisms of Induction and Maintenance
(PowerPoint Slides)

Robert D. Blitzer*

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.


*Corresponding author. E-mail: robert.blitzer{at}


Slides are provided for a class covering a particular type of synaptic plasticity called long-term potentiation (LTP) and are part of the course �Cell Signaling Systems: A Course for Graduate Students.� Topics include the signaling network responsible for LTP induction, evidence for upregulated postsynaptic mechanisms in LTP, and the role of dendritic protein synthesis in LTP. The slides and lecture focus on what has been learned from studies in rodent brain slices, particularly at the CA3-CA1 synapse of the hippocampus.

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Educational Details

Learning Resource Type: PowerPoint slides

Context: Undergraduate upper division, graduate, professional (degree program)

Intended Users: Teacher, learner

Intended Educational Use: Teach, learn, plan

Discipline: Neurobiology, Biochemistry, Molecular Biology, Pharmacology, Structural Biology

Keywords: long-term potentiation, synaptic plasticity, postsynaptic signaling, NMDA, memory

Technical Details

Format: PowerPoint (ppt)

Size: 16.2 MB

Requirements: Microsoft PowerPoint

Limits for Use

Cost: Free

Rights: This material may be downloaded for noncommercial, course-teaching purposes only, provided credit to STKE is included by listing the citation for the Teaching Resource.


Citation: R. D. Blitzer, Long-term potentiation: Mechanisms of induction and maintenance. Sci. STKE2005, tr26 (2005).

© 2005 American Association for the Advancement of Science