Regulation of Complexes by Cytoskeletal Elements:
Integrins Serve as Force Transducers Linking Mechanical Stimuli and Biochemical Signals
(PowerPoint Slides and Movie)
Dan P. Felsenfeld*
*Corresponding author. E-mail:
Slides and a movie are provided for a class covering the integrin family members and the downstream signaling pathways they activate and are part of the course �Cell Signaling Systems: A Course for Graduate Students.� The lecture focuses on the capacity of integrins to serve as mechanotransducers, with particular emphasis on signaling mechanisms downstream of integrins.
The movie is the author's work and shows the interaction of NIH 3T3 fibroblasts with beads coated with the integrin-binding domain of fibronectin (FNIII 7-10), which illustrates the ligand-dependent association between integrins and treadmilling actin in the cytosol. Slide 10 is where this movie fits into the slides. Similar results have been published by Felsenfeld et al. [Nature 383, 438-440 (1996)].
Learning Resource Types: PowerPoint slides and movie
Context: Undergraduate upper division, graduate, professional (degree program)
Intended Users: Teacher, learner
Intended Educational Use: Teach, learn, plan
Discipline: Biochemistry, molecular biology, pharmacology, structural biology, cell biology
Keywords: Integrins, extracellular matrix, adhesion receptors, cell motility, mechanotransduction
Format: PowerPoint (ppt)
Size: 33.5 MB
Requirements: Microsoft PowerPoint
Format: QuickTime Movie (mov)
Size: 15.2 MB
Requirements: QuickTime Player
Limits for Use
Rights: This material may be downloaded for noncommercial, course-teaching purposes only, provided credit to STKE is included by listing the citation for the Teaching Resource.
Citation: D.P. Felsenfeld, Regulation of complexes by cytoskeletal elements: Integrins as force transducers: a link between mechanical stimuli and biochemical signals. Sci. STKE2005, tr27 (2005).