Supplemental Table

TGF-β Signaling in Development (Supplemental Table)

Krit Kitisin,1 Tapas Saha,1 Tiffany Blake,1 Nady Golestaneh,1 Merlyn Deng,1 Christine Kim,1 Yi Tang,1 Kirti Shetty,1 Bibhuti Mishra,1 Lopa Mishra1,2*

1Laboratory of Cancer Genetics and Digestive Diseases, Departments of Surgery, Medicine, and LCCC, Georgetown University, Washington, DC 20007, USA. 2DVAMC, Washington, DC 20007, USA.

Supplemental Table. TGF-β signaling in development based on mouse knockout and mutant analysis.


Developmental stage or processLigandsReceptorsIntracellular signaling molecules Citations

Primitive streak formationNodalALK2,

ActRII,

ActRIIB
Smad2,

Smad4
1

Mesoderm formationBMP2,

BMP4,

Nodal
ALK2,

ALK3,

ALK4
Smad2,

Smad4
1, 2

Endoderm formationCripto,

Nodal,

BMP4
ALK2,

ActRI
Smad43, 2, 4

Cardiac developmentBMP2,

Cripto,

Endoglin
ActRIIB,

ALK2
Smad4,

Smad5,

Smad6
5, 6

Kidney developmentBMP7,

BMP2,

BMP4
ALK4,

BMPRII,

BMPRIA,

BMPRIB
Smad1,

Smad4,

Smad5,

Smad8
7

Bone developmentTGF-β2,

TGF-β3,

BMP4
ALK6,

ActRIIA
Smad1,

Smad5,

Smad8
1

Liver and gastrointestinal tract developmentBMP1,

BMP4,

BMP7
BMPR1A,

ActRII,

ActRIIB
Smad2,

Smad3,

ELF,

Smad4
7, 8

Vasculogenesis and hematopoesisTGF-β1TβRI,

TβRII
Smad59, 10, 11

E-mail, lopamishra{at}yahoo.com

References

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    Citation: K. Kitisin, T. Saha, T. Blake, N. Golestaneh, M. Deng, C. Kim, Y. Tang, K. Shetty, B. Mishra, L. Mishra, TGF-β signaling in development. Sci. STKE (Connections Map in Database of Cell Signaling, as seen July 2007) http://stke.sciencemag.org/cgi/cm/stkecm;CMP_18196.

    Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882