Dok-7 Activates the Muscle Receptor Kinase MuSK and Shapes Synapse Formation
Akane Inoue, Kiyoko Setoguchi, Yosuke Matsubara, Kumiko Okada, Nozomi Sato, Yoichiro Iwakura, Osamu Higuchi, Yuji Yamanashi*
*To whom correspondence should be addressed. E-mail:
This PDF file includes:
- Fig. S1. The pHSA-Dok-7-EGFP transgene is overexpressed in skeletal muscle.
- Fig. S2. The number of myofibers was comparable in WT and Dok-7 Tg mice.
- Fig. S3. AChR clusters formed only in Dok-7–/– myotubes that express Dok-7-EGFP.
- Fig. S4. Transcripts for endogenous Dok-7 were distributed uniformly throughout the muscle at E18.5.
- Fig. S5. The Myc epitope appropriately increased the molecular mass of phosphorylated MuSK-cyt.
- Fig. S6. Dok-7 activated MuSK-cyt.
- Fig. S7. MuSK was not activated by a Dok-7 deletion mutant lacking the PH domain or the Dok-family protein Dok-1.
- Fig. S8. The pHSA-Dok-7-Myc transgene is overexpressed in skeletal muscle.
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