Supplementary Materials

Supplementary Materials for:

Suppression of LPS-Induced TNF-α Production in Macrophages by cAMP Is Mediated by PKA-AKAP95-p105

Estelle A. Wall, Joelle R. Zavzavadjian, Mi Sook Chang, Baljinder Randhawa, Xiaocui Zhu, Robert C. Hsueh, Jamie Liu, Adrienne Driver, Xiaoyan Robert Bao, Paul C. Sternweis, Melvin I. Simon, Iain D. C. Fraser*

*To whom correspondence should be addressed. E-mail: fraseri{at}

This PDF file includes:

  • Fig. S1. Expression of PKA and EPAC mRNAs in RAW264.7 cells.
  • Fig. S2. Specificities of PKA-anchoring inhibitor peptides.
  • Fig. S3. RNAi-mediated knockdown of Creb1a mRNA in RAW264.7 cells.
  • Fig. S4. The effect of PGE2 on LPS-induced phosphorylation of MAPKs.
  • Fig. S5. The effect of cAMP on LPS-induced phosphorylation of p65 at Ser536.
  • Fig. S6. Relative abundance of endogenous AKAPs in RAW 264.7 cells.

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Citation: E. A. Wall, J. R. Zavzavadjian, M. S. Chang, B. Randhawa, X. Zhu, R. C. Hsueh, J. Liu, A. Driver, X. R. Bao, P. C. Sternweis, M. I. Simon, I. D. C. Fraser, Suppression of LPS-Induced TNF-α production in macrophages by cAMP is mediated by PKA-AKAP95- p105. Sci. Signal.2, ra28 (2009).

© 2009 American Association for the Advancement of Science