Supplementary Materials

Supplementary Materials for:

Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases

Chris Soon Heng Tan, Bernd Bodenmiller, Adrian Pasculescu, Marko Jovanovic, Michael O. Hengartner, Claus J�rgensen, Gary D. Bader, Ruedi Aebersold, Tony Pawson, Rune Linding*

*To whom correspondence should be addressed. E-mail: linding{at}icr.ac.uk

This PDF file includes:

  • Methods
  • Fig. S1. Clustering analysis of core phosphorylation sites.
  • Fig. S2. Phosphorylatable residues in disordered regions are fast evolving.
  • Fig. S3. Phosphorylation site disorder analysis.
  • Fig. S4. Schematic diagram of how the conserved phosphorylation propensity k of each human substrate is computed.
  • Fig. S5. Box plot of number of human substrate relations observed as conserved in target species from randomized trials.
  • Fig. S6. Core sites observed in activation loops of protein kinases.
  • Table S1. Statistical significance of core sites observed between human and yeast.
  • Table S2. Statistical significance of core sites observed between human and fly.
  • Table S3. Statistical significance of core sites observed between human and worm.
  • Table S4. Core sites identified in components of the β-catenin destruction complex.
  • Table S5. Core sites identified in components of the clathrin coat of coated pits.
  • Table S6. Core site identified in 22 cancer-associated genes.
  • Table S7. Correlation of cancer-associated genes with conserved phosphorylation propensity k computed for individual target species.
  • Table S8. Correlation of OMIM genes with conserved phosphorylation propensity k computed for individual target species.
  • References
  • Supplementary Data File Descriptions

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Other Supplementary Materials for this manuscript include the following:



Supplementary Data (ZIP file containing files in cys, tsv, txt, csv, and fa formats)


Citation: C. S. H. Tan, B. Bodenmiller, A. Pasculescu, M. Jovanovic, M. O. Hengartner, C. J�rgensen, G. D. Bader, R. Aebersold, T. Pawson, R. Linding, Comparative Analysis Reveals Conserved Protein Phosphorylation Networks Implicated in Multiple Diseases. Sci. Signal.2, ra39 (2009).

© 2009 American Association for the Advancement of Science