Supplementary Materials

Supplementary Materials for:

Rapid Evolution of Functional Complexity in a Domain Family

Andreas Ernst, Stephen L. Sazinsky, Shirley Hui, Bridget Currell, Moyez Dharsee, Somasekar Seshagiri, Gary D. Bader, Sachdev S. Sidhu*

*To whom correspondence should be addressed. E-mail: sachdev.sidhu{at}

This PDF file includes:

  • Table S1. Structure-selected Erbin-PDZ variants.
  • Table S2. IC50 values for synthetic peptides binding to PDZ domains.
  • Fig. S1. Binding of Erbin-PDZ to synthetic peptides.
  • Fig. S2. Comparison of binding site similarity and specificity profile similarity for Erbin-PDZ variants.
  • Fig. S3. Two-dimensional representation of PDZ domain specificity space.
  • Fig. S4. Tree representation of the specificity profiles of Erbin-PDZ variants.

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Citation: A. Ernst, S. L. Sazinsky, S. Hui, B. Currell, M. Dharsee, S. Seshagiri, G. D. Bader, S. S. Sidhu, Rapid evolution of functional complexity in a domain family. Sci. Signal.2, ra50 (2009).

© 2009 American Association for the Advancement of Science