Supplementary Materials

Supplementary Materials for:

Leishmania GP63 Alters Host Signaling Through Cleavage-Activated Protein Tyrosine Phosphatases

Maria Adelaida Gomez, Irazu Contreras, Maxime Hallé, Michel L. Tremblay, Robert W.

McMaster, Martin Olivier*

*To whom correspondence should be addressed. E-mail: martin.olivier{at}mcgill.ca

This PDF file includes:

  • Methods
  • Fig. S1. Distribution of PTPs after Leishmania infection.
  • Fig. S2. Pattern of PTP activity upon infection with different Leishmania species.
  • Fig. S3. Putative cleavage sites in the PTPs.
  • Fig. S4. Targeted deletion of putative cleavage sites.
  • Fig. S5. Recombinant GP63 mediates PTP cleavage in cell lysates.
  • Fig. S6. MβCD cytotoxicity.
  • Fig. S7. Colocalization of GP63 and the lipid raft marker CTxB.
  • Fig. S8. Leishmania infection triggers PTP1B cleavage in SHP-1–/– MØs.
  • Fig. S9. Cleaved PTPs partially disappear after 24 hours of infection.
  • Table S1. Putative GP63 cleavage sites.
  • References

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Technical Details

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Citation: M. A. Gomez, I. Contreras, M. Hall�, M. L. Tremblay, R. W. McMaster, M. Olivier, Leishmania GP63 Alters Host Signaling Through Cleavage-Activated Protein Tyrosine Phosphatases. Sci. Signal. 2, ra58 (2009).

© 2009 American Association for the Advancement of Science