Science Signaling Podcast: 5 January 2010

Participants: Michael B. Yaffe and Annalisa M. VanHook

A conversation about a Research Articles published in Science Signaling in 2009.

Highlighted articles:

M. B. Major, R. T. Moon, "Omic" risk assessment. Sci. Signal. 2, eg7 (2009).

Q.-W. Fan, C. Cheng, Z. A. Knight, D. Haas-Kogan, D. Stokoe, C. D. James, F. McCormick, K. M. Shokat, W. A. Weiss, EGFR signals to mTOR through PKC and independently of Akt in glioma. Sci. Signal. 2, ra4 (2009).

C.-Y. Wang, H.-H. Kim, Y. Hiroi, N. Sawada, S. Salomone, L. E. Benjamin, K. Walsh, M. A. Moskowitz, J. K. Liao, Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR. Sci. Signal. 2, ra11 (2009).

J. Macia, S. Regot, T. Peeters, N. Conde, R. Sol�, F. Posas, Dynamic signaling in the Hog1 MAPK pathway relies on high basal signal transduction. Sci. Signal. 2, ra13 (2009).

R. C. Hsueh, M. Natarajan, I. Fraser, B. Pond, J. Liu, S. Mumby, H. Han, L. I. Jiang, M. I. Simon, R. Taussig, P. C. Sternweis, Deciphering signaling outcomes from a system of complex networks. Sci. Signal. 2, ra22 (2009).

F. Golebiowski, I. Matic, M. H. Tatham, C. Cole, Y. Yin, A. Nakamura, J. Cox, G. J. Barton, M. Mann, R. T. Hay, System-wide changes to SUMO modifications in response to heat shock. Sci. Signal. 2, ra24 (2009).

B. Schoeberl, E. A. Pace, J. B. Fitzgerald, B. D. Harms, L. Xu, L. Nie, B. Linggi, A. Kalra, V. Paragas, R. Bukhalid, V. Grantcharova, N. Kohli, K. A. West, M. Leszczyniecka, M. J. Feldhaus, A. J. Kudla, U. B. Nielsen, Therapeutically targeting ErbB3: A key node in ligand-induced activation of the ErbB receptor�PI3K axis. Sci. Signal. 2, ra31 (2009).

B. Diaz, G. Shani, I. Pass, D. Anderson, M. Quintavalle, S. A. Courtneidge, Tks5-dependent, Nox-mediated generation of reactive oxygen species is necessary for invadopodia formation. Sci. Signal. 2, ra53 (2009).

D. Gianni, B. Diaz, N. Taulet, B. Fowler, S. A. Courtneidge, G. M. Bokoch, Novel p47phox-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. Sci. Signal. 2, ra54 (2009).

T. K. Lee, E. M. Denny, J. C. Sanghvi, J. E. Gaston, N. D. Maynard, J. J. Hughey, M. W. Covert, A noisy paracrine signal determines the cellular NF-κB response to lipopolysaccharide. Sci. Signal. 2, ra65 (2009).

C. Chen, Y. Liu, Y. Liu, P. Zheng, mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci. Signal 2, ra75 (2009).

R. Cheong, C. J. Wang, A. Levchenko, Using a microfluidic device for high-content analysis of cell signaling. Sci. Signal. 2, pl2 (2009).

Length: 12 minutes

File size: 5.7 MB

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