Supplementary Materials

Supplementary Materials for:

DNA-PKcs Controls an Endosomal Signaling Pathway for a Proinflammatory Response by Natural Killer Cells

Sumati Rajagopalan,* Mark W. Moyle, Irma Joosten, Eric O. Long*

*To whom correspondence should be addressed. E-mail: sumi{at}nih.gov (S.R.) and eLong{at}nih.gov (E.O.L.)

This PDF file includes:

  • Fig. S1. The CD158d-gp49 chimera traffics to the same endosomal compartments as does wild-type CD158d.
  • Fig. S2. Stimulation of CD158d in resting NK cells results in the phosphorylation of Akt at Ser473, but not Thr308.
  • Fig. S3. Inhibition of the CD158d-dependent secretion of IFN-γ and IL-8.
  • Fig. S4. CD158d colocalizes with Rab5 and Rab5Q79L in endosomes.
  • Fig. S5. Akt is present in endosomes that contain CD158d and Rab5Q79L.
  • Fig. S6. Colocalization profiles of CD158d, Rab5Q79L, and Akt.
  • Table S1. Compounds tested for their ability to inhibit CD158d-dependent secretion of IFN-γ by resting NK cells.

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Citation: S. Rajagopalan, M. W. Moyle, I. Joosten, E. O. Long, DNA-PKcs Controls an Endosomal Signaling Pathway for a Proinflammatory Response by Natural Killer Cells. Sci. Signal. 3, ra14 (2010).

© 2010 American Association for the Advancement of Science