Supplementary Materials

Supplementary Materials for:

Differential Redox Regulation of ORAI Ion Channels: A Mechanism to Tune Cellular Calcium Signaling

Ivan Bogeski,* Carsten Kummerow, Dalia Al-Ansary, Eva C. Schwarz, Richard Koehler, Daisuke Kozai, Nobuaki Takahashi, Christine Peinelt, Desiree Griesemer, Monika Bozem, Yasuo Mori, Markus Hoth, Barbara A. Niemeyer*

*To whom correspondence should be addressed. E-mail: ivan.bogeski{at}uks.eu (I.B.); barbara.niemeyer{at}uks.eu (B.A.N.)

This PDF file includes:

  • Fig. S1. Activated CRAC channels are not inhibited by H2O2.
  • Fig. S2. H2O2 effect on ORAI2 and current/voltage relationships of ORAI1WT, ORAI1TM, ORAI1C195S, and ORAI3WT.
  • Fig. S3. H2O2 activates nonselective ion channels.
  • Fig. S4. Orai3 siRNA down-regulates ORAI3 protein.
  • Fig. S5. Relative amounts and activity of cellular antioxidants in naïve and effector TH cells.

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Citation: I. Bogeski, C. Kummerow, D. Al-Ansary, E. C. Schwarz, R. Koehler, D. Kozai, N. Takahashi, C. Peinelt, D. Griesemer, M. Bozem, Y. Mori, M. Hoth, B. A. Niemeyer, Differential Redox Regulation of ORAI Ion Channels: A Mechanism to Tune Cellular Calcium Signaling. Sci. Signal. 3, ra24 (2010).

© 2010 American Association for the Advancement of Science