Science Signaling Podcast: 4 January 2011

Participants: Michael B. Yaffe and Annalisa M. VanHook

A conversation about Research Articles published in Science Signaling in 2010 and a look ahead to 2011.

Highlighted articles, in the order in which they are discussed:

E. M. Adler, 2010: Signaling Breakthroughs of the Year. Sci. Signal. 4, eg1 (2011).

Z. Wang, N. D. Udeshi, C. Slawson, P. D. Compton, K. Sakabe, W. D. Cheung, J. Shabanowitz, D. F. Hunt, G. W. Hart, Extensive Crosstalk Between O-GlcNAcylation and Phosphorylation Regulates Cytokinesis. Sci. Signal. 3, ra2 (2010).

C. H. Eng, K. Yu, J. Lucas, E. White, R. T. Abraham, Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy. Sci. Signal. 3, ra31 (2010).

D. Q. Matus, X. Y. Li, S. Durbin, D. Agarwal, Q. Chi, S. J. Weiss, D. R. Sherwood, In Vivo Identification of Regulators of Cell Invasion Across Basement Membranes. Sci. Signal. 3, ra35 (2010).

I. Michaelevski, Y. Segal-Ruder, M. Rozenbaum, K. F. Medzihradszky, O. Shalem, G. Coppola, S. Horn-Saban, K. Ben-Yaakov, S. Y. Dagan, I. Rishal, D. H. Geschwind, Y. Pilpel, A. L. Burlingame, M. Fainzilber, Signaling to Transcription Networks in the Neuronal Retrograde Injury Response. Sci. Signal. 3, ra53 (2010).

E. Slinger, D. Maussang, A. Schreiber, M. Siderius, A. Rahbar, A. Fraile-Ramos, S. A. Lira, C. S�derberg-Naucl�r, M. J. Smit, HCMV-Encoded Chemokine Receptor US28 Mediates Proliferative Signaling Through the IL-6�STAT3 Axis. Sci. Signal. 3, ra58 (2010).

Q. Ye, S. W. Crawley, Y. Yang, G. P. C�t�, Z. Jia, Crystal Structure of the α-Kinase Domain of Dictyostelium Myosin Heavy Chain Kinase A. Sci. Signal. 3, ra17 (2010).

T. Maruyama, A. J. Mirando, C. X. Deng, W. Hsu, The Balance of WNT and FGF Signaling Influences Mesenchymal Stem Cell Fate During Skeletal Development. Sci. Signal. 3, ra40 (2010).

J. Kwon, K. E. Shatynski, H. Chen, S. Morand, X. de Deken, F. Miot, T. L. Leto, M. S. Williams, The Nonphagocytic NADPH Oxidase Duox1 Mediates a Positive Feedback Loop During T Cell Receptor Signaling. Sci. Signal. 3, ra59 (2010).

F. Ramadani, D. J. Bolland, F. Garcon, J. L. Emery, B. Vanhaesebroeck, A. E. Corcoran, K. Okkenhaug, The PI3K Isoforms p110α and p110δ Are Essential for Pre�B Cell Receptor Signaling and B Cell Development. Sci. Signal. 3, ra60 (2010).

Y. Chen, Y. Yao, Y. Sumi, A. Li, U. K. To, A. Elkhal, Y. Inoue, T. Woehrle, Q. Zhang, C. Hauser, W. G. Junger, Purinergic Signaling: A Fundamental Mechanism in Neutrophil Activation. Sci. Signal. 3, ra45 (2010).

M. Kronlage, J. Song, L. Sorokin, K. Isfort, T. Schwerdtle, J. Leipziger, B. Robaye, P. B. Conley, H.-C. Kim, S. Sargin, P. Sch�n, A. Schwab, P. J. Hanley, Autocrine Purinergic Receptor Signaling Is Essential for Macrophage Chemotaxis. Sci. Signal. 3, ra55 (2010).

V. Mieulet, L. Yan, C. Choisy, K. Sully, J. Procter, A. Kouroumalis, S. Krywawych, M. Pende, S. C. Ley, C. Moinard, R. F. Lamb, TPL-2�Mediated Activation of MAPK Downstream of TLR4 Signaling Is Coupled to Arginine Availability. Sci. Signal. 3, ra61 (2010).

J. E. Qualls, G. Neale, A. M. Smith, M.-S. Koo, A. A. DeFreitas, H. Zhang, G. Kaplan, S. S. Watowich, P. J. Murray, Arginine Usage in Mycobacteria-Infected Macrophages Depends on Autocrine-Paracrine Cytokine Signaling. Sci. Signal. 3, ra62 (2010).

I. Astsaturov, V. Ratushny, A. Sukhanova, M. B. Einarson, T. Bagnyukova, Y. Zhou, K. Devarajan, J. S. Silverman, N. Tikhmyanova, N. Skobeleva, A. Pecherskaya, R. E. Nasto, C. Sharma, S. A. Jablonski, I. G. Serebriiskii, L. M. Weiner, E. A. Golemis, Synthetic Lethal Screen of an EGFR-Centered Network to Improve Targeted Therapies. Sci. Signal. 3, ra67 (2010).

Q.-W. Fan, C. Cheng, C. Hackett, M. Feldman, B. T. Houseman, T. Nicolaides, D. Haas-Kogan, C. D. James, S. A. Oakes, J. Debnath, K. M. Shokat, W. A. Weiss, Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma. Sci. Signal. 3, ra81 (2010).

L. Poliseno, L. Salmena, L. Riccardi, A. Fornari, M. S. Song, R. M. Hobbs, P. Sportoletti, S. Varmeh, A. Egia, G. Fedele, L. Rameh, M. Loda, P. P. Pandolfi, Identification of the miR-106b~25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation. Sci. Signal. 3, ra29 (2010).

R. Avraham, A. Sas-Chen, O. Manor, I. Steinfeld, R. Shalgi, G. Tarcic, N. Bossel, A. Zeisel, I. Amit, Y. Zwang, E. Enerly, H. G. Russnes, F. Biagioni, M. Mottolese, S. Strano, G. Blandino, A.-L. B�rresen-Dale, Y. Pilpel, Z. Yakhini, E. Segal, Y. Yarden, EGF Decreases the Abundance of MicroRNAs That Restrain Oncogenic Transcription Factors. Sci. Signal. 3, ra43 (2010).

M. Stapels, C. Piper, T. Yang, M. Li, C. Stowell, Z.-g. Xiong, J. Saugstad, R. P. Simon, S. Geromanos, J. Langridge, J.-q. Lan, A. Zhou, Polycomb Group Proteins as Epigenetic Mediators of Neuroprotection in Ischemic Tolerance. Sci. Signal. 3, ra15 (2010).

J. V. Olsen, M. Vermeulen, A. Santamaria, C. Kumar, M. L. Miller, L. J. Jensen, F. Gnad, J. Cox, T. S. Jensen, E. A. Nigg, S. Brunak, M. Mann, Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis. Sci. Signal. 3, ra3 (2010).

Length: 13 minutes

File size: 8.1 MB

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