Supplementary Materials

Supplementary Materials for:

ERKs Induce Expression of the Transcriptional Repressor Blimp-1 and Subsequent Plasma Cell Differentiation

Tomoharu Yasuda, Kohei Kometani, Noriko Takahashi, Yuuki Imai, Yuichi Aiba, Tomohiro Kurosaki*

*To whom correspondence should be addressed. E-mail: kurosaki{at}rcai.riken.jp

This PDF file includes:

  • Fig. S1. Normal B cell development in Cγ1-Cre-ERKdKO mice.
  • Fig. S2. Antibody responses to the immunization of ERK1-deficient, ERK2-deficient, and ERK double-deficient mice with NP-CGG and alum.
  • Fig. S3. Generation of GC B cells.
  • Fig. S4. The NP-specific IgG1 response of Cγ1-Cre or Cγ1-Cre-ERKdKO mice harboring the Bcl2 transgene.
  • Fig. S5. Effect of ERK deficiency on the numbers of IgM ASCs.
  • Fig. S6. Normal Prdm1 expression in ERK double-deficient cells still restores the defect in plasma cell differentiation.
  • Fig. S7. Phosphorylation of STAT3 on Ser727 depends on ERKs, but is not required for plasma cell differentiation.
  • Fig. S8. Overexpression of Blimp-1 induces the expression of Xbp1.

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Citation: T. Yasuda, K. Kometani, N. Takahashi, Y. Imai, Y. Aiba, T. Kurosaki, ERKs Induce Expression of the Transcriptional Repressor Blimp-1 and Subsequent Plasma Cell Differentiation. Sci. Signal. 4, ra25 (2011).

© 2011 American Association for the Advancement of Science