Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling
Jamie R. Schoenborn, Ying Xim Tan, Chao Zhang, Kevan M. Shokat, Arthur Weiss*
*To whom correspondence should be addressed. E-mail:
This PDF file includes:
- Fig. S1. Screen of PP1 analogs for a specific inhibitor of CskAS.
- Fig. S2. Phosphorylation of ζ chain and its association with ZAP-70 upon inhibition of CskAS.
- Fig. S3. Inhibition of CskAS in primary mouse T cells activates Lck and ERK.
- Fig. S4. CskAS activity regulates the amount of the TCR at the cell surface.
- Fig. S5. Cellular activation induced by CskAS inhibition requires TCR at the cell surface, but is not dependent on the amount of TCR.
- Fig. S6. Increase in TCR abundance in response to CskAS is not required for cellular activation upon inhibition of CskAS.
- Fig. S7. Identification of Dok-1 as p65 by mass spectrometric analysis of CskAS immunoprecipitates.
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Citation: J. R. Schoenborn, Y. X. Tan, C. Zhang, K. M. Shokat, A. Weiss, Feedback Circuits Monitor and Adjust Basal Lck-Dependent Events in T Cell Receptor Signaling. Sci. Signal. 4, ra59 (2011).