Supplementary Materials

Bistability in Biochemical Signaling Models (Slides, Problem Set, Answer Key)

Eric A. Sobie*

*Contact information. E-mail, eric.sobie{at}

Slides. Bistability in biochemical siganling models. This Presentation contains slides for two lectures in a graduate course on computational biology. The lectures discuss concepts underlying bistability in biochemical signaling networks.

Technical Details

Format: PowerPoint (.ppt)

Size: 3.86 MB

Requirements: Microsoft PowerPoint

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Problem set. Two MATLAB files for performing computational analysis of bistability. “ratebalance.m”, which generates rate balance plots for cases with (i) no feedback or (ii) ultrasensitive feedback, and “repression.m”, which consists of an ODE model of a generic two variable system with mutual repression.

Technical Details

Format: M file (.m)

Size: 1-2 KB (each)

Requirements: MATLAB

[Download zip file with Problem Set MATLAB codes]

Answer Key. The answer key for the problem set can be obtained by completing the “Request Resource” form. The answer key includes four MATLAB files and a PDF showing the graphs.

Technical Details

Format: M (.m), PDF (.pdf)

Size: 1-2 KB (MATLAB files); PDF, 54 KB

Requirements: MATLAB, Adobe Acrobat Reader

Limits for Use

Cost: Free

Rights: This material may be downloaded for noncommercial, course-teaching purposes only, provided credit to Science Signaling is included by listing the citation for the Teaching Resource.

Citation: E. A. Sobie, Bistability in Biochemical Signaling Models. Sci. Signal. 4, tr10 (2011).

© 2011 American Association for the Advancement of Science