The Long-Term Survival Potential of Mature T Lymphocytes Is Programmed During Development in the Thymus
Charles Sinclair, Manoj Saini, Ina Schim van der Loeff, Shimon Sakaguchi, Benedict Seddon*
*To whom correspondence should be addressed. E-mail:
This PDF file includes:
- Fig. S1. IL-7Rα abundance on peripheral T cells from F5 and OT-I mice is not tuned by spMHC contact in replete b2m–/– hosts.
- Fig. S2. Prior contact of F5 T cells with spMHC does not determine their proliferative response to IL-7 in vitro.
- Fig. S3. IL-7Rα abundance and function in OT-I T cells in the absence of TCR ligands are normal.
- Fig. S4. CD8 abundance on CD8+ cells from TCR transgenic and Zap70 mutant mice is unchanged.
- Fig. S5. IL-7Rα abundance inversely correlates with clonal competition in mixed bone marrow chimeric mice.
- Fig. S6. IL-7Rαhi and IL-7Rαlo CD4+ SP thymocytes have equivalent maturation
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Citation: C. Sinclair, M. Saini, I. S. van der Loeff, S. Sakaguchi, B. Seddon, The Long-Term Survival Potential of Mature T Lymphocytes Is Programmed During Development in the Thymus. Sci. Signal. 4, ra77 (2011).