Cannabinoids Induce Pancreatic β-Cell Death by Directly Inhibiting Insulin Receptor Activation
Wook Kim, Qizong Lao, Yu-Kyong Shin, Olga D. Carlson, Eun Kyung Lee, Myriam Gorospe, Rohit N. Kulkarni, Josephine M. Egan*
*To whom correspondence should be addressed. E-mail:
This PDF file includes:
- Fig. S1. CB1 receptor abundance in pancreatic β-cell lines.
- Fig. S2. Effects of ACEA depend on the CB1 receptor.
- Fig. S3. Effects of WIN55,212-2 on human hepatocarcinoma HepG2 cells and primary human hepatocytes.
- Fig. S4. Effects of Gαi3 on insulin receptor signaling.
- Fig. S5. Improved β-cell mass due to enhanced β-cell survival in STZ-treated CB1R–/– mice.
- Fig. S6. Enhanced insulin signaling in β cells of STZ-treated CB1R–/– mice.
- Fig. S7. Increased phosphorylation of p27 at Ser10 and Thr157 in islets of STZ-treated mice by CB1 receptor blockade.
- Fig. S8. Increased abundance of PDX-1, GLUT2, and glucokinase in β cells of STZ-treated CB1R–/–mice.
- Table S1. Details of the antibodies used for immunoblotting, immunoprecipitation,
and immunofluorescence studies.
Format: Adobe Acrobat PDF
Size: 842 KB
Citation: W. Kim, Q. Lao, Y.-K. Shin, O. D. Carlson, E. K. Lee, M. Gorospe, R. N. Kulkarni, J. M. Egan, Cannabinoids Induce Pancreatic β-Cell Death by Directly Inhibiting Insulin Receptor Activation. Sci. Signal. 5, ra23 (2012).