Supplementary Materials

Supplementary Materials for:

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

Agnes Roczniak-Ferguson, Constance S. Petit, Florian Froehlich, Sharon Qian, Jennifer Ky, Brittany Angarola, Tobias C. Walther, Shawn M. Ferguson*

*To whom correspondence should be addressed. E-mail: shawn.ferguson{at}yale.edu

This PDF file includes:

  • Fig. S1. Regulation of TFEB localization by lysosomal status.
  • Fig. S2. 14-3-3 proteins are major binding partners of TFEB.
  • Fig. S3. Relationship between TFEB, mTOR, and lysosomes.
  • Fig. S4. MITF and TFE3 localization is sensitive to lysosome status.
  • Movie S1 legend

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mov format). Time-lapse imaging of TFEB-GFP.

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Format: Quicktime Movie

Size: 1.88 MB


Citation: A. Roczniak-Ferguson, C. S. Petit, F. Froehlich, S. Qian, J. Ky, B. Angarola, T. C. Walther, S. M. Ferguson, The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis. Sci. Signal. 5, ra42 (2012).

© 2012 American Association for the Advancement of Science