Supplementary Materials

Supplementary Materials for:

Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation

Nikolaos Patsoukis, Julia Brown, Victoria Petkova, Fang Liu, Lequn Li, Vassiliki A. Boussiotis*

*To whom correspondence should be addressed. E-mail: vboussio{at}bidmc.harvard.edu

This PDF file includes:

  • Fig. S1. Effects of PD-1 signaling on cell cycle progression.
  • Fig. S2. PD-1 inhibits the kinase activity of Cdk2.
  • Fig. S3. Neutralization of TGF-β does not reverse the effect of PD-1 signaling on the transcriptional activation of Smad3 or the antiproliferative function of PD-1.
  • Fig. S4. PD-1 signaling inhibits activation of Akt and phosphorylation of GSK-3.

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Citation: N. Patsoukis, J. Brown, V. Petkova, F. Liu, L. Li, V. A. Boussiotis, Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation. Sci. Signal. 5, ra46 (2012).

© 2012 American Association for the Advancement of Science