Supplementary Materials

Supplementary Materials for:

Inositol Polyphosphate Multikinase Is a Coactivator of p53-Mediated Transcription and Cell Death

Risheng Xu, Nilkantha Sen, Bindu D. Paul, Adele M. Snowman, Feng Rao, M. Scott Vandiver, Jing Xu, Solomon H. Snyder*

*Corresponding author. E-mail: ssnyder{at}jhmi.edu

This PDF file includes:

  • Fig. S1. IPMK regulates expression of p53 downstream targets.
  • Fig. S2. IPMK is depleted with shRNA.
  • Fig. S3. Protein abundance of p53 targets is decreased by IPMK depletion.
  • Fig. S4. Abundance of p53 target proteins increased by IPMK is p53-dependent.
  • Fig. S5. IPMK binds the PUMA promoter.
  • Fig. S6. Genetic deletion of IPMK decreases p53 binding to its target promoters.
  • Fig. S7. IPMK inhibits cell proliferation.

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Citation: R. Xu, N. Sen, B. D. Paul, A. M. Snowman, F. Rao, M. S. Vandiver, J. Xu, S. H. Snyder, Inositol Polyphosphate Multikinase is a Coactivator of p53-Mediated Transcription and Cell Death. Sci. Signal. 6, ra22 (2013).

© 2013 American Association for the Advancement of Science