Coupled Transport Protein Systems (Animations)

Jack D. Thatcher*


Animation 1. Gastric pumps. This FLASH animation illustrates HCl secretion into the gastric lumen as an example of a coupled system of transport proteins.

[Download Animation in FLASH format for PC] (link to the file called Gastric Pumps.swf)

[Download Animation for Mac] (link to the file called Transport Gastric

Animation 2. Glucose absorption. This FLASH animation depicts glucose absorption into intestinal epithelial cells through a coupled system of transport proteins.

[Download Animation in FLASH format for PC] (link to the file called Glucose Absorption.swf)

[Download Animation for Mac] (link to the file called Glucose

Animation 3. CFTR. This FLASH animation depicts the cystic fibrosis conductance transmembrane regulator (CFTR) functioning as a key component of a coupled system of transport proteins that increases the NaCl concentration in pulmonary mucus.

[Download Animation in FLASH format for PC] (link to the file called CFTR.swf)

[Download Animation for Mac] (link to the file called

Technical Instructions

To open the animations with a Windows operating system using Internet Explorer, follow these steps:
(1) Click the link for the animation.
(2) A dialog box may pop up that begins with the statement "Windows cannot open this file." If this box does not appear, proceed to step four. If it does, choose "Select the program from a list," then click OK.
(3) Another dialog box will pop up that lists different programs. Make sure "Internet Explorer" is selected, then click OK.
(4) Internet Explorer will pop up. Beneath the toolbars at the top of the window, a yellow bar will appear that reads: "To help protect your security, Internet Explorer has restricted this Web page from running scripts or Active X controls that could access your computer. Click here for options�." Pass the cursor over this yellow bar and click the right mouse button.
(5) A dialog box will pop up. Left click the option "Allow Blocked Content."
(6) Another dialog box will appear labeled "Security Warning" asking you to confirm that you want to run the content. Click "Yes."
(7) The Flash animation will appear in the Internet Explorer Window.
(8) Instructions for navigating the lesson are provided by the first frame of the animation. On most screens, unless specified, clicking anywhere on the screen advances the action.
To play the animations on a Mac, unzip the file and double click the icon for the application.

Technical Details

Format: FLASH animation

Size: 39 kb (Gastric Pumps.swf), 54 kb (Glucose Absorption.swf), 109 kb (CFTR.swf)

Requirements: Flash-enabled Web browser

Limits for Use

Cost: Free

Rights: This material may be downloaded for noncommercial, course-teaching purposes only, provided credit to Science Signaling is included by listing the citation for the Teaching Resource.

Citation: J. D. Thatcher, Coupled transport protein systems. Sci. Signal. 6, tr5 (2013).

© 2013 American Association for the Advancement of Science