An Increase in Synaptic NMDA Receptors in the Insular Cortex Contributes to Neuropathic Pain
Shuang Qiu, Tao Chen, Kohei Koga, Yan-yan Guo, Hui Xu, Qian Song, Jie-jie Wang, Giannina Descalzi, Bong-Kiun Kaang, Jian-hong Luo, Min Zhuo,* Ming-gao Zhao*
This PDF file includes:
- Fig. S1. Enhancement of behavioral sensitization (allodynia) to nerve injury in wild-type mice.
- Fig. S2. Subcellular fractionation of synaptosomes.
- Fig. S3. The amount of NMDARs in insular cortical homogenates from wild-type mice shows no change on day 7 after nerve injury.
- Fig. S4. Comparison of the amounts of GluN2B and GluN2A in insular cortical homogenates from wild-type, AC1−/−, AC8−/−, and AC1&AC8−/− mice.
- Fig. S5. Elimination of behavioral sensitization to nerve injury in AC8−/− mice but not in AC1−/− mice.
- Fig. S6. Forskolin and rolipram treatment does not affect the amount of synaptic NMDARs in insular cortical slices from AC8−/− mice.
- Fig. S7. ESI-09 does not affect the increase in the amount of synaptic GluN2B or GluN2A induced by forskolin and rolipram.
- Fig. S8. PP2 blocks the increase in the amount of synaptic GluN2B and GluN2A induced by forskolin and rolipram.
Format: Adobe Acrobat PDF
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Citation: S. Qiu, T. Chen, K. Koga, Y.-y. Guo, H. Xu, Q. Song, J.-j. Wang, G. Descalzi, B.-K. Kaang, J.-h. Luo, M. Zhuo, M.-g. Zhao, An Increase in Synaptic NMDA Receptors in the Insular Cortex Contributes to Neuropathic Pain. Sci. Signal. 6, ra34 (2013).