Supplementary Materials

Supplementary Materials for:

Arginine Methylation of CRTC2 Is Critical in the Transcriptional Control of Hepatic Glucose Metabolism

Hye-Sook Han, Chang-Yun Jung, Young-Sil Yoon, Seri Choi, Dahee Choi, Geon Kang, Keun-Gyu Park, Seong-Tae Kim, Seung-Hoi Koo*

*Corresponding author. E-mail: koohoi@korea.ac.kr

This PDF file includes:

  • Fig. S1. PRMT6 enhances CRTC2-dependent transcription.
  • Fig. S2. Six arginine residues in CRTC2 are dimethylated.
  • Fig. S3. PRMT6 targets conserved arginine residues of CRTC families.
  • Fig. S4. PRMT6 is critical for CRTC2-dependent regulation of gluconeogenic genes in hepatocytes.
  • Fig. S5. CRTC2 is crucial in mediating PRMT6-dependent control of hepatic glucose metabolism in hepatocytes.
  • Fig. S6. Knockdown of PRMT6 reduces the expression of gluconeogenic genes in insulin-resistant state.
  • Fig. S7. PRMT6 is critical in mediating the fasting response to CRTC2-dependent gluconeogenesis.
  • Table S1. Identification of CRTC2-interacting proteins.

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Citation: H.-S. Han, C.-Y. Jung, Y.-S. Yoon, S. Choi, D. Choi, G. Kang, K.-G. Park, S.-T. Kim, S.-H. Koo, Arginine Methylation of CRTC2 Is Critical in the Transcriptional Control of Hepatic Glucose Metabolism. Sci. Signal. 7, ra19 (2014).

© 2014 American Association for the Advancement of Science