Supplementary Materials

Supplementary Materials for:

Tumor Necrosis Factor Suppresses NR5A2 Activity and Intestinal Glucocorticoid Synthesis to Sustain Chronic Colitis

Sheng-Chieh Huang, Cheng-tse Lee, Bon-chu Chung*

*Corresponding author. E-mail: mbchung@sinica.edu.tw

This PDF file includes:

  • Fig. S1. Characterization of DSS-induced chronic colitis.
  • Fig. S2. Long-term DSS-induced chronic colitis results in a reduction in the abundances of Cyp11a1 and Cyp11b1 mRNAs.
  • Fig. S3. Effects of different cytokines on NR5A2-induced changes in Cyp11a1 and Cyp11b1 expression in mICc12 cells.
  • Fig. S4. Effect of TNF on the survival of colonic primary crypts.
  • Fig. S5. Involvement of NF-κB and JNK in the TNF-mediated suppression of steroidogenic gene expression in mICc12 cells.
  • Fig. S6. XPro1595 reduces intestinal NF-κB and JNK activation during DSS-induced chronic colitis.
  • Table S1. PCR primers used in this study.

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Citation: S.-C. Huang, C.-t. Lee, B.-c. Chung, Tumor Necrosis Factor Suppresses NR5A2 Activity and Intestinal Glucocorticoid Synthesis to Sustain Chronic Colitis. 7, ra20 (2014).

© 2014 American Association for the Advancement of Science