Supplementary Materials

Supplementary Materials for:

BRAF Inhibitors Induce Metastasis in RAS Mutant or Inhibitor-Resistant Melanoma Cells by Reactivating MEK and ERK Signaling

Berta Sanchez-Laorden, Amaya Viros, Maria Romina Girotti, Malin Pedersen, Grazia Saturno, Alfonso Zambon, Dan Niculescu-Duvaz, Samra Turajlic, Andrew Hayes, Martin Gore, James Larkin, Paul Lorigan, Martin Cook, Caroline Springer, Richard Marais*

*Corresponding author. E-mail: richard.marais@cruk.manchester.ac.uk

This PDF file includes:

  • Fig. S1. BRAF inhibition induces a metastatic phenotype in RAS mutant tumors.
  • Fig. S2. BRAFV600E inhibitor–resistant melanoma cells display a metastatic phenotype.
  • Table S1. BRAF inhibition induces metastasis in RASG12D mutant tumors.
  • Table S2. BRAF inhibitors induce protease-dependent invasion in RAS mutant melanoma cells.
  • Table S3. Cell shape quantification.
  • Table S4. Responses to vemurafenib in BRAF mutant melanoma patients.
  • Table S5. Abundance of uPA in patient melanoma samples before and after vemurafenib treatment.
  • Table S6. Cell lines and mutational status.

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Technical Details

Format: Adobe Acrobat PDF

Size: 1.80 MB

Other Supplementary Material for this manuscript includes the following:

  • Table S2A (Microsoft Excel format)

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Citation: B. Sanchez-Laorden, A. Viros, M. R. Girotti, M. Pedersen, G. Saturno, A. Zambon, D. Niculescu-Duvaz, S. Turajlic, A. Hayes, M.Gore, J. Larkin, P. Lorigan, M. Cook, C. Springer, R. Marais, BRAF Inhibitors Induce Metastasis in RAS Mutant or Inhibitor-Resistant Melanoma Cells By Reactivating MEK and ERK Signaling. Sci. Signal. 7, ra30 (2014).

© 2014 American Association for the Advancement of Science