Supplementary Materials

Supplementary Materials for:

Targeting Poly(ADP-Ribose) Polymerase and the c-Myb–Regulated DNA Damage Response Pathway in Castration-Resistant Prostate Cancer

Likun Li, Wenjun Chang, Guang Yang, Chengzhen Ren, Sanghee Park, Theodoros Karantanos, Styliani Karanika, Jianxiang Wang, Jianhua Yin, Parantu K. Shah, Hirayama Takahiro, Masato Dobashi, Wenling Zhang, Eleni Efstathiou, Sankar N. Maity, Ana M. Aparicio, Elsa M. Li Ning Tapia, Patricia Troncoso, Bradley Broom, Lianchun Xiao, Hyun-Sung Lee, Ju-Seog Lee, Paul G. Corn, Nora Navone, Timothy C. Thompson*

*Corresponding author. E-mail: timthomp{at}mdanderson.org

This PDF file includes:

  • Fig. S1. Correlation analysis of MYB and AR mRNA expression in PCa.
  • Fig. S2. MYB mRNA expression under different conditions that impair AR signaling.
  • Fig. S3. qRT-PCR validation of AR and c-Myb co-regulated DDR genes.
  • Table S1. Clinical treatment associated with PCa bone biopsies.
  • Table S2. PDX information.
  • Table S3. Genes differentially expressed by either AR or MYB knockdown.
  • Table S4. Combinatorial effects of DDR-associated gene silencing and PARP inhibition on PCa cells.
  • Table S5. Determination of synergy.
  • Table S6. Primer sequences.
  • Table S7. siRNA and shRNA sequences.
  • References (38, 39)

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Citation: L. Li, W. Chang, G. Yang, C. Ren, S. Park, T. Karantanos, S. Karanika, J. Wang, J. Yin, P. K. Shah, H. Takahiro, M. Dobashi, W. Zhang, E. Efstathiou, S. N. Maity, A. M. Aparicio, E. M. Li Ning Tapia, P. Troncoso, B. Broom, L. Xiao, H.-S. Lee, J.-S. Lee, P. G. Corn, N. Navone, T. C. Thompson, Targeting Poly(ADP-Ribose) Polymerase and the c-Myb–Regulated DNA Damage Response Pathway in Castration-Resistant Prostate Cancer. Sci. Signal. 7, ra47 (2014).

© 2014 American Association for the Advancement of Science