Supplementary Materials

This PDF file includes:

  • Fig. S1. TLR3 induces cell death–independent, caspase-8–dependent processing of p62 at Asp329.
  • Fig. S2. Caspase-8–dependent processing of p62 at Asp329.
  • Fig. S3. Role of RIPK1 in p62TRM production and the instability of the p62330–440 fragment.
  • Fig. S4. Characterization of p62TRM.
  • Fig. S5. Characterization of p62TRM, p62D329, p62D329H, and other variants.
  • Fig. S6. Synthetic cleavage of p62 using TEV.
  • Fig. S7. Role of RIPK1 and caspase-8 in mTORC1 regulation.
  • Fig. S8. Role of p62 variants and RIPK1 in regulating mTORC1.
  • Table S1. List of antibodies.
  • Table S2. List of key reagents and resources.
  • Table S3. siRNA sequences used in the study.

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