Supplementary Materials

This PDF file includes:

  • Fig. S1. Detection of the Y399F mutation engineered into the Ptpro gene of mice.
  • Fig. S2. OCLs from WT and ROKO mice.
  • Fig. S3. Verification of engraftment after bone marrow transplantation.
  • Fig. S4. Activity of WT PTPROt and several PTPROt mutants toward PNPP.
  • Fig. S5. PTPROt pTyr399 binds to specific SH2 domains.
  • Fig. S6. PTPROt coprecipitates with Grb2 in a phosphorylation-dependent manner.
  • Fig. S7. Staining of OCLs with antibodies against Src and HA.
  • Table S1. ╬╝CT analysis of tibiae from WT-HA-PTPROt versus Y399F-HA-PTPROt (line 16) mice.

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