Error message

No crossref credentials set for pnas

MicroRNA-155 is induced during the macrophage inflammatory response

PNAS, 30 January 2007
Vol. 104, Issue 5, p. 1604-1609
DOI: 10.1073/pnas.0610731104

MicroRNA-155 is induced during the macrophage inflammatory response

  1. Ryan M. O'Connell *,
  2. Konstantin D. Taganov *,
  3. Mark P. Boldin *,
  4. Genhong Cheng , and
  5. David Baltimore * ,
  1. *Department of Biology, California Institute of Technology, 330 Braun, 1200 East California Boulevard, Pasadena, CA 91125; and
  2. Departments of Microbiology, Immunology, and Molecular Genetics, University of California, 650 Charles East Young Drive South, Los Angeles, CA 90095
  1. Contributed by David Baltimore, December 4, 2006 (received for review November 10, 2006)

Abstract

The mammalian inflammatory response to infection involves the induction of several hundred genes, a process that must be carefully regulated to achieve pathogen clearance and prevent the consequences of unregulated expression, such as cancer. Recently, microRNAs (miRNAs) have emerged as a class of gene expression regulators that has also been linked to cancer. However, the relationship between inflammation, innate immunity, and miRNA expression is just beginning to be explored. In the present study, we use microarray technology to identify miRNAs induced in primary murine macrophages after exposure to polyriboinosinic:polyribocytidylic acid or the cytokine IFN-β. miR-155 was the only miRNA of those tested that was substantially up-regulated by both stimuli. It also was induced by several Toll-like receptor ligands through myeloid differentiation factor 88- or TRIF-dependent pathways, whereas up-regulation by IFNs was shown to involve TNF-α autocrine signaling. Pharmacological inhibition of the kinase JNK blocked induction of miR-155 in response to either polyriboinosinic:polyribocytidylic acid or TNF-α, suggesting that miR-155-inducing signals use the JNK pathway. Together, these findings characterize miR-155 as a common target of a broad range of inflammatory mediators. Importantly, because miR-155 is known to function as an oncogene, these observations identify a potential link between inflammation and cancer.

  • cancer
  • inflammation
  • innate immunity
  • cytokines

Footnotes

  • To whom correspondence should be addressed. E-mail: baltimo{at}caltech.edu
  • Author contributions: R.M.O. and K.D.T. designed research; R.M.O. and K.D.T. performed research; R.M.O., M.P.B., G.C., and D.B. contributed new reagents/analytic tools; R.M.O., K.D.T., M.P.B., G.C., and D.B. analyzed data; and R.M.O. and D.B. wrote the paper.

  • The authors declare no conflict of interest.

  • This article contains supporting information online at www.pnas.org/cgi/content/full/0610731104/DC1.

  • Abbreviations:
    miRNA,
    microRNA;
    LPS,
    lipopolysaccharide;
    MyD88,
    myeloid differentiation factor 88;
    poly(I:C),
    polyriboinosinic polyribocytidylic acid;
    qPCR,
    quantitative PCR;
    TLR,
    Toll-like receptor.
  • Freely available online through the PNAS open access option.

Citation:

R. M. O'Connell, K. D. Taganov, M. P. Boldin, G. Cheng, and D. Baltimore, MicroRNA-155 is induced during the macrophage inflammatory response. PNAS 104, 1604-1609 (2007).

Exosome-Mediated Transfer of microRNAs Within the Tumor Microenvironment and Neuroblastoma Resistance to Chemotherapy
K. B. Challagundla, P. M. Wise, P. Neviani, H. Chava, M. Murtadha, T. Xu, R. Kennedy, C. Ivan, X. Zhang, I. Vannini et al.
JNCI J Natl Cancer Inst 107, djv135-djv135 (13 May 2015)

MicroRNA-155 in the Heart: The Right Time at the Right Place in the Right Cell
K. J. Rayner, P. M. Wise, P. Neviani, H. Chava, M. Murtadha, T. Xu, R. Kennedy, C. Ivan, X. Zhang, I. Vannini et al.
Circulation 131, 1533-1535 (5 May 2015)

MicroRNA-155 Exerts Cell-Specific Antiangiogenic but Proarteriogenic Effects During Adaptive Neovascularization
F. Pankratz, X. Bemtgen, R. Zeiser, F. Leonhardt, S. Kreuzaler, I. Hilgendorf, C. Smolka, T. Helbing, I. Hoefer, J. S. Esser et al.
Circulation 131, 1575-1589 (5 May 2015)

Suppression of Transforming Growth Factor {beta} Receptor 2 and Smad5 Is Associated with High Levels of MicroRNA miR-155 in the Oral Mucosa during Chronic Simian Immunodeficiency Virus Infection
J. George, M. G. Lewis, R. Renne, and J. J. Mattapallil
J. Virol. 89, 2972-2978 (1 March 2015)

Circulating and renal vein levels of microRNAs in patients with renal artery stenosis
M. Y. Park, S. M. Herrmann, A. Saad, R. J. Widmer, H. Tang, X.-Y. Zhu, A. Lerman, S. C. Textor, and L. O. Lerman
Nephrol Dial Transplant 30, 480-490 (1 March 2015)

MicroRNAs: new players in IBD
R. Kalla, N. T. Ventham, N. A. Kennedy, J. F. Quintana, E. R. Nimmo, A. H. Buck, and J. Satsangi
Gut 64, 504-513 (1 March 2015)

Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21
C. I. Caescu, X. Guo, L. Tesfa, T. D. Bhagat, A. Verma, D. Zheng, and E. R. Stanley
Blood 125, e1-e13 (19 February 2015)

miR-24, miR-30b, and miR-142-3p Regulate Phagocytosis in Myeloid Inflammatory Cells
A. R. Naqvi, J. B. Fordham, and S. Nares
J. Immunol. 194, 1916-1927 (15 February 2015)

Promoter Occupancy of STAT1 in Interferon Responses Is Regulated by Processive Transcription
I. Wiesauer, C. Gaumannmuller, I. Steinparzer, B. Strobl, and P. Kovarik
Mol. Cell. Biol. 35, 716-727 (15 February 2015)

MiR-127 Modulates Macrophage Polarization and Promotes Lung Inflammation and Injury by Activating the JNK Pathway
H. Ying, Y. Kang, H. Zhang, D. Zhao, J. Xia, Z. Lu, H. Wang, F. Xu, and L. Shi
J. Immunol. 194, 1239-1251 (1 February 2015)

Host miR155 Promotes Tumor Growth through a Myeloid-Derived Suppressor Cell-Dependent Mechanism
S. Chen, L. Wang, J. Fan, C. Ye, D. Dominguez, Y. Zhang, T. J. Curiel, D. Fang, T. M. Kuzel, B. Zhang et al.
Cancer Res. 75, 519-531 (1 February 2015)

IL-10 regulates Aicda expression through miR-155
K. A. Fairfax, M. P. Gantier, F. Mackay, B. R. G. Williams, and C. E. McCoy
J. Leukoc. Biol. 97, 71-78 (1 January 2015)

Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model
J. R. Guedes, C. M. Custodia, R. J. Silva, L. P. de Almeida, M. C. Pedroso de Lima, and A. L. Cardoso
Hum Mol Genet 23, 6286-6301 (1 December 2014)

MicroRNA-155 potentiates the inflammatory response in hypothermia by suppressing IL-10 production
A. T. Billeter, J. Hellmann, H. Roberts, D. Druen, S. A. Gardner, H. Sarojini, S. Galandiuk, S. Chien, A. Bhatnagar, M. Spite et al.
FASEB J. 28, 5322-5336 (1 December 2014)

The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation
D. Lu, R. Nakagawa, S. Lazzaro, P. Staudacher, C. Abreu-Goodger, T. Henley, S. Boiani, R. Leyland, A. Galloway, S. Andrews et al.
JEM 211, 2183-2198 (20 October 2014)

Virus Meets Host MicroRNA: the Destroyer, the Booster, the Hijacker
Y. E. Guo, and J. A. Steitz
Mol. Cell. Biol. 34, 3780-3787 (15 October 2014)

IFN-{gamma} Primes Macrophage Activation by Increasing Phosphatase and Tensin Homolog via Downregulation of miR-3473b
C. Wu, Y. Xue, P. Wang, L. Lin, Q. Liu, N. Li, J. Xu, and X. Cao
J. Immunol. 193, 3036-3044 (15 September 2014)

Tongxinluo inhibits vascular inflammation and neointimal hyperplasia through blockade of the positive feedback loop between miR-155 and TNF-{alpha}
R.-n. Zhang, B. Zheng, L.-m. Li, J. Zhang, X.-h. Zhang, and J.-k. Wen
Am. J. Physiol. Heart Circ. Physiol. 307, H552-H562 (15 August 2014)

Early MicroRNA Expression Profile as a Prognostic Biomarker for the Development of Pelvic Inflammatory Disease in a Mouse Model of Chlamydial Genital Infection
L. Yeruva, G. S. A. Myers, N. Spencer, H. H. Creasy, N. E. Adams, A. T. Maurelli, G. R. McChesney, M. A. Cleves, J. Ravel, A. Bowlin et al.
mBio 5, e01241-14-e01241-14 (1 July 2014)

microRNA-224 regulates Pentraxin 3, a component of the humoral arm of innate immunity, in inner ear inflammation
A. Rudnicki, S. Shivatzki, L. A. Beyer, Y. Takada, Y. Raphael, and K. B. Avraham
Hum Mol Genet 23, 3138-3146 (15 June 2014)

MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation
M. A. Lopez-Ramirez, D. Wu, G. Pryce, J. E. Simpson, A. Reijerkerk, J. King-Robson, O. Kay, H. E. de Vries, M. C. Hirst, B. Sharrack et al.
FASEB J. 28, 2551-2565 (1 June 2014)

Intestinal Epithelial Barrier Disruption through Altered Mucosal MicroRNA Expression in Human Immunodeficiency Virus and Simian Immunodeficiency Virus Infections
C. A. Gaulke, M. Porter, Y.-H. Han, S. Sankaran-Walters, I. Grishina, M. D. George, A. T. Dang, S.-W. Ding, G. Jiang, I. Korf et al.
J. Virol. 88, 6268-6280 (1 June 2014)

MicroRNA-155 Deficiency Results in Decreased Macrophage Inflammation and Attenuated Atherogenesis in Apolipoprotein E-Deficient Mice
F. Du, F. Yu, Y. Wang, Y. Hui, K. Carnevale, M. Fu, H. Lu, and D. Fan
Arterioscler. Thromb. Vasc. Bio. 34, 759-767 (1 April 2014)

The Role of Ets2 Transcription Factor in the Induction of MicroRNA-155 (miR-155) by Lipopolysaccharide and Its Targeting by Interleukin-10
S. R. Quinn, N. E. Mangan, B. E. Caffrey, M. P. Gantier, B. R. G. Williams, P. J. Hertzog, C. E. McCoy, and L. A. J. O'Neill
J Biol Chem 289, 4316-4325 (14 February 2014)

microRNAs in the onset and development of cardiovascular disease
K. C. Vickers, K.-A. Rye, and F. Tabet
Clin. Sci. 126, 183-194 (1 February 2014)

The long noncoding RNA THRIL regulates TNF{alpha} expression through its interaction with hnRNPL
Z. Li, T.-C. Chao, K.-Y. Chang, N. Lin, V. S. Patil, C. Shimizu, S. R. Head, J. C. Burns, and T. M. Rana
Proc. Natl. Acad. Sci. USA 111, 1002-1007 (21 January 2014)

miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis
T.-C. Chao, K.-Y. Chang, N. Lin, V. S. Patil, C. Shimizu, S. R. Head, J. C. Burns, and T. M. Rana
elife 3, e01964-e01964 (1 January 2014)

MicroRNA-155 Tunes Both the Threshold and Extent of NK Cell Activation via Targeting of Multiple Signaling Pathways
R. P. Sullivan, L. A. Fogel, J. W. Leong, S. E. Schneider, R. Wong, R. Romee, T.-H. Thai, V. Sexl, S. J. Matkovich, G. W. Dorn et al.
J. Immunol. 191, 5904-5913 (15 December 2013)

Macrophage MicroRNA-155 Promotes Cardiac Hypertrophy and Failure
S. Heymans, M. F. Corsten, W. Verhesen, P. Carai, R. E. W. van Leeuwen, K. Custers, T. Peters, M. Hazebroek, L. Stoger, E. Wijnands et al.
Circulation 128, 1420-1432 (24 September 2013)

Interferon Regulatory Factor 4 Is Activated through c-Src-Mediated Tyrosine Phosphorylation in Virus-Transformed Cells
L. Wang, and S. Ning
J. Virol. 87, 9672-9679 (1 September 2013)

miR-155-Deficient Bone Marrow Promotes Tumor Metastasis
F. Yu, X. Jia, F. Du, J. Wang, Y. Wang, W. Ai, and D. Fan
Mol Cancer Res 11, 923-936 (1 August 2013)

MicroRNAs in flow-dependent vascular remodelling
P. Neth, M. Nazari-Jahantigh, A. Schober, and C. Weber
Cardiovasc Res 99, 294-303 (15 July 2013)

A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice
E. Zonari, F. Pucci, M. Saini, R. Mazzieri, L. S. Politi, B. Gentner, and L. Naldini
Blood 122, 243-252 (11 July 2013)

Negative regulation of Toll-like receptor 4 signaling by IL-10-dependent microRNA-146b
G. Curtale, M. Mirolo, T. A. Renzi, M. Rossato, F. Bazzoni, and M. Locati
Proc. Natl. Acad. Sci. USA 110, 11499-11504 (9 July 2013)

miR-155 in Acute Myeloid Leukemia: Not Merely a Prognostic Marker?
C. E. Joyce, and C. D. Novina
JCO 31, 2219-2221 (10 June 2013)

Clinical Role of microRNAs in Cytogenetically Normal Acute Myeloid Leukemia: miR-155 Upregulation Independently Identifies High-Risk Patients
G. Marcucci, K. S. Maharry, K. H. Metzeler, S. Volinia, Y.-Z. Wu, K. Mrozek, D. Nicolet, J. Kohlschmidt, S. P. Whitman, J. H. Mendler et al.
JCO 31, 2086-2093 (10 June 2013)

Autoantibody Induction by DNA-Containing Immune Complexes Requires HMGB1 with the TLR2/MicroRNA-155 Pathway
Z. Wen, L. Xu, X. Chen, W. Xu, Z. Yin, X. Gao, and S. Xiong
J. Immunol. 190, 5411-5422 (1 June 2013)

miR-155 Regulates Immune Modulatory Properties of Mesenchymal Stem Cells by Targeting TAK1-binding Protein 2
C. Xu, G. Ren, G. Cao, Q. Chen, P. Shou, C. Zheng, L. Du, X. Han, M. Jiang, Q. Yang et al.
J Biol Chem 288, 11074-11079 (19 April 2013)

The microRNA-342-5p Fosters Inflammatory Macrophage Activation Through an Akt1- and microRNA-155-Dependent Pathway During Atherosclerosis
Y. Wei, M. Nazari-Jahantigh, L. Chan, M. Zhu, K. Heyll, J. Corbalan-Campos, P. Hartmann, A. Thiemann, C. Weber, A. Schober et al.
Circulation 127, 1609-1619 (16 April 2013)

Pathogenic arterial remodeling: the good and bad of microRNAs
Y. Wei, A. Schober, and C. Weber
Am. J. Physiol. Heart Circ. Physiol. 304, H1050-H1059 (15 April 2013)

1,25-Dihydroxyvitamin D Promotes Negative Feedback Regulation of TLR Signaling via Targeting MicroRNA-155-SOCS1 in Macrophages
Y. Chen, W. Liu, T. Sun, Y. Huang, Y. Wang, D. K. Deb, D. Yoon, J. Kong, R. Thadhani, Y. C. Li et al.
J. Immunol. 190, 3687-3695 (1 April 2013)

Combined Serum CA19-9 and miR-27a-3p in Peripheral Blood Mononuclear Cells to Diagnose Pancreatic Cancer
W.-S. Wang, L.-X. Liu, G.-P. Li, Y. Chen, C.-Y. Li, D.-Y. Jin, and X.-L. Wang
Cancer Prev Res 6, 331-338 (1 April 2013)

An Extraribosomal Function of Ribosomal Protein L13a in Macrophages Resolves Inflammation
D. Poddar, A. Basu, W. M. Baldwin, R. V. Kondratov, S. Barik, and B. Mazumder
J. Immunol. 190, 3600-3612 (1 April 2013)

Differential microRNA (miRNA) expression could explain microbial tolerance in a novel chronic peritonitis model
Z. Kanaan, R. Barnett, S. Gardner, B. Keskey, D. Druen, A. Billeter, and W. G. Cheadle
Innate Immunity 19, 203-212 (1 April 2013)

MicroRNA-126, -145, and -155: A Therapeutic Triad in Atherosclerosis?
Y. Wei, M. Nazari-Jahantigh, P. Neth, C. Weber, and A. Schober
Arterioscler. Thromb. Vasc. Bio. 33, 449-454 (1 March 2013)

MicroRNAs and respiratory diseases
H. Rupani, T. Sanchez-Elsner, and P. Howarth
Eur Respir J 41, 695-705 (1 March 2013)

Enhanced Susceptibility to Citrobacter rodentium Infection in MicroRNA-155-Deficient Mice
S. Clare, V. John, A. W. Walker, J. L. Hill, C. Abreu-Goodger, C. Hale, D. Goulding, T. D. Lawley, P. Mastroeni, G. Frankel et al.
Infect. Immun. 81, 723-732 (1 March 2013)

Rat mir-155 generated from the lncRNA Bic is 'hidden' in the alternate genomic assembly and reveals the existence of novel mammalian miRNAs and clusters
P. Uva, L. Da Sacco, M. Del Corno, A. Baldassarre, P. Sestili, M. Orsini, A. Palma, S. Gessani, and A. Masotti
RNA 19, 365-379 (1 March 2013)

Genome-Wide Analyses of Amphioxus MicroRNAs Reveal an Immune Regulation via miR-92d Targeting C3
R. Yang, T. Zheng, X. Cai, Y. Yu, C. Yu, L. Guo, S. Huang, W. Zhu, R. Zhu, Q. Yan et al.
J. Immunol. 190, 1491-1500 (15 February 2013)

A Newly Identified MicroRNA, mmu-miR-7578, Functions as a Negative Regulator on Inflammatory Cytokines Tumor Necrosis Factor-{alpha} and Interleukin-6 via Targeting Egr1 in Vivo
J. Zhang, S. Xie, W. Ma, Y. Teng, Y. Tian, X. Huang, and Y. Zhang
J Biol Chem 288, 4310-4320 (8 February 2013)

Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis
A. Mildner, E. Chapnik, O. Manor, S. Yona, K.-W. Kim, T. Aychek, D. Varol, G. Beck, Z. B. Itzhaki, E. Feldmesser et al.
Blood 121, 1016-1027 (7 February 2013)

Coordinated regulation of synthesis and stability of RNA during the acute TNF-induced proinflammatory response
M. T. Paulsen, A. Veloso, J. Prasad, K. Bedi, E. A. Ljungman, Y.-C. Tsan, C.-W. Chang, B. Tarrier, J. G. Washburn, R. Lyons et al.
Proc. Natl. Acad. Sci. USA 110, 2240-2245 (5 February 2013)

Micro-RNA 155 Is Required for Optimal CD8+ T Cell Responses to Acute Viral and Intracellular Bacterial Challenges
E. F. Lind, A. R. Elford, and P. S. Ohashi
J. Immunol. 190, 1210-1216 (1 February 2013)

MicroRNAs in Immune Response and Macrophage Polarization
G. Liu, and E. Abraham
Arterioscler. Thromb. Vasc. Bio. 33, 170-177 (1 February 2013)

In Vitro Sensitivity of CLL Cells to Fludarabine May Be Modulated by the Stimulation of Toll-like Receptors
E. Fonte, B. Apollonio, L. Scarfo, P. Ranghetti, C. Fazi, P. Ghia, F. Caligaris-Cappio, and M. Muzio
Clin. Cancer Res. 19, 367-379 (15 January 2013)

Tolerization of Inflammatory Gene Expression
J. J. Seeley, and S. Ghosh
Cold Spring Harb Symp Quant Biol 78, 69-79 (1 January 2013)

Respiratory Syncytial Virus Regulates Human MicroRNAs by Using Mechanisms Involving Beta Interferon and NF-{kappa}B
N. J. Thornburg, S. L. Hayward, and J. E. Crowe
mBio 3, e00220-12-e00220-12 (31 December 2012)

Essential Role of MicroRNA-155 in Regulating Endothelium-Dependent Vasorelaxation by Targeting Endothelial Nitric Oxide Synthase
H.-X. Sun, D.-Y. Zeng, R.-T. Li, R.-P. Pang, H. Yang, Y.-L. Hu, Q. Zhang, Y. Jiang, L.-Y. Huang, Y.-B. Tang et al.
Hypertension 60, 1407-1414 (1 December 2012)

Proteasomal Degradation of Nod2 Protein Mediates Tolerance to Bacterial Cell Wall Components
K.-H. Lee, A. Biswas, Y.-J. Liu, and K. S. Kobayashi
J Biol Chem 287, 39800-39811 (16 November 2012)

MicroRNA 21 in tissue injury and inflammation: AUTHORS' RETROSPECTIVE
C. K. Sen, and S. Roy
Cardiovasc Res 96, 230-233 (1 November 2012)

Respiratory syncytial virus modifies microRNAs regulating host genes that affect virus replication
A. Bakre, P. Mitchell, J. K. Coleman, L. P. Jones, G. Saavedra, M. Teng, S. M. Tompkins, and R. A. Tripp
J. Gen. Virol. 93, 2346-2356 (1 November 2012)

MicroRNAs and Their Target Genes in Gingival Tissues
C. Stoecklin-Wasmer, P. Guarnieri, R. Celenti, R. T. Demmer, M. Kebschull, and P. N. Papapanou
JDR 91, 934-940 (1 October 2012)

Expression, Circulation, and Excretion Profile of MicroRNA-21, -155, and -18a Following Acute Kidney Injury
J. Saikumar, D. Hoffmann, T.-M. Kim, V. R. Gonzalez, Q. Zhang, P. L. Goering, R. P. Brown, V. Bijol, P. J. Park, S. S. Waikar et al.
Toxicol Sci 129, 256-267 (1 October 2012)

Tissue- and Plasma-Specific MicroRNA Signatures for Atherosclerotic Abdominal Aortic Aneurysm
K. Kin, S. Miyagawa, S. Fukushima, Y. Shirakawa, K. Torikai, K. Shimamura, T. Daimon, Y. Kawahara, T. Kuratani, Y. Sawa et al.
JAHA 1, e000745-e000745 (4 September 2012)

Decreased microRNA-155 Expression in Ocular Behcet's Disease but Not in Vogt Koyanagi Harada Syndrome
Q. Zhou, X. Xiao, C. Wang, X. Zhang, F. Li, Y. Zhou, A. Kijlstra, and P. Yang
IOVS 53, 5665-5674 (17 August 2012)

MicroRNA Profiling Identifies MicroRNA-155 as an Adverse Mediator of Cardiac Injury and Dysfunction During Acute Viral Myocarditis
M. F. Corsten, A. Papageorgiou, W. Verhesen, P. Carai, M. Lindow, S. Obad, G. Summer, S. L. M. Coort, M. Hazebroek, R. van Leeuwen et al.
Circ. Res. 111, 415-425 (3 August 2012)

Identification of Resting and Type I IFN-Activated Human NK Cell miRNomes Reveals MicroRNA-378 and MicroRNA-30e as Negative Regulators of NK Cell Cytotoxicity
P. Wang, Y. Gu, Q. Zhang, Y. Han, J. Hou, L. Lin, C. Wu, Y. Bao, X. Su, M. Jiang et al.
J. Immunol. 189, 211-221 (1 July 2012)

miRNA-125b regulates TNF-{alpha} production in CD14+ neonatal monocytes via post-transcriptional regulation
H.-C. Huang, H.-R. Yu, L.-T. Huang, H.-C. Huang, R.-F. Chen, I.-C. Lin, C.-Y. Ou, T.-Y. Hsu, and K. D. Yang
J. Leukoc. Biol. 92, 171-182 (1 July 2012)

Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma
I. A. Babar, C. J. Cheng, C. J. Booth, X. Liang, J. B. Weidhaas, W. M. Saltzman, and F. J. Slack
Proc. Natl. Acad. Sci. USA 109, E1695-E1704 (26 June 2012)

Identifying Functional MicroRNAs in Macrophages with Polarized Phenotypes
J. W. Graff, A. M. Dickson, G. Clay, A. P. McCaffrey, and M. E. Wilson
J Biol Chem 287, 21816-21825 (22 June 2012)

Integrin CD11b Negatively Regulates TLR9-Triggered Dendritic Cell Cross-Priming by Upregulating microRNA-146a
Y. Bai, C. Qian, L. Qian, F. Ma, J. Hou, Y. Chen, Q. Wang, and X. Cao
J. Immunol. 188, 5293-5302 (1 June 2012)

Induction of microRNA-155 is TLR- and type IV secretion system-dependent in macrophages and inhibits DNA-damage induced apoptosis
M. Koch, H.-J. Mollenkopf, U. Klemm, and T. F. Meyer
Proc. Natl. Acad. Sci. USA 109, E1153-E1162 (8 May 2012)

The emerging role of microRNA in regulation of endotoxin tolerance
E. M. Quinn, J. Wang, and H. P. Redmond
J. Leukoc. Biol. 91, 721-727 (1 May 2012)

A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells
S. Jiang, L.-F. Zhang, H.-W. Zhang, S. Hu, M.-H. Lu, S. Liang, B. Li, Y. Li, D. Li, E.-D. Wang et al.
EMBO J. 31, 1985-1998 (18 April 2012)

Reprogramming Tumor-Associated Dendritic Cells In Vivo Using miRNA Mimetics Triggers Protective Immunity against Ovarian Cancer
J. R. Cubillos-Ruiz, J. R. Baird, A. J. Tesone, M. R. Rutkowski, U. K. Scarlett, A. L. Camposeco-Jacobs, J. Anadon-Arnillas, N. M. Harwood, M. Korc, S. N. Fiering et al.
Cancer Res. 72, 1683-1693 (1 April 2012)

Non-cardiomyocyte microRNAs in heart failure
A. J. Tijsen, Y. M. Pinto, and E. E. Creemers
Cardiovasc Res 93, 573-582 (15 March 2012)

miR-30 Family Members Negatively Regulate Osteoblast Differentiation
T. Wu, H. Zhou, Y. Hong, J. Li, X. Jiang, and H. Huang
J Biol Chem 287, 7503-7511 (2 March 2012)

Microbiota Downregulates Dendritic Cell Expression of miR-10a, Which Targets IL-12/IL-23p40
X. Xue, T. Feng, S. Yao, K. J. Wolf, C.-G. Liu, X. Liu, C. O. Elson, and Y. Cong
J. Immunol. 187, 5879-5886 (1 December 2011)

Integrative Deep Sequencing of the Mouse Lung Transcriptome Reveals Differential Expression of Diverse Classes of Small RNAs in Response to Respiratory Virus Infection
X. Peng, L. Gralinski, M. T. Ferris, M. B. Frieman, M. J. Thomas, S. Proll, M. J. Korth, J. R. Tisoncik, M. Heise, S. Luo et al.
mBio 2, e00198-11-e00198-11 (15 November 2011)

MicroRNA-155 Promotes Resolution of Hypoxia-Inducible Factor 1{alpha} Activity during Prolonged Hypoxia
U. Bruning, L. Cerone, Z. Neufeld, S. F. Fitzpatrick, A. Cheong, C. C. Scholz, D. A. Simpson, M. O. Leonard, M. M. Tambuwala, E. P. Cummins et al.
Mol. Cell. Biol. 31, 4087-4096 (1 October 2011)

MicroRNA-155 Is Essential for the T Cell-Mediated Control of Helicobacter pylori Infection and for the Induction of Chronic Gastritis and Colitis
M. Oertli, D. B. Engler, E. Kohler, M. Koch, T. F. Meyer, and A. Muller
J. Immunol. 187, 3578-3586 (1 October 2011)

MicroRNA function in myeloid biology
R. M. O'Connell, J. L. Zhao, and D. S. Rao
Blood 118, 2960-2969 (15 September 2011)

Silencing MicroRNA-155 Ameliorates Experimental Autoimmune Encephalomyelitis
G. Murugaiyan, V. Beynon, A. Mittal, N. Joller, and H. L. Weiner
J. Immunol. 187, 2213-2221 (1 September 2011)

Oncogenic IRFs Provide a Survival Advantage for Epstein-Barr Virus- or Human T-Cell Leukemia Virus Type 1-Transformed Cells through Induction of BIC Expression
L. Wang, N. L. Toomey, L. A. Diaz, G. Walker, J. C. Ramos, G. N. Barber, and S. Ning
J. Virol. 85, 8328-8337 (15 August 2011)

MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis
M. Hulsmans, D. De Keyzer, and P. Holvoet
FASEB J. 25, 2515-2527 (1 August 2011)

MicroRNA Expression Profiles of Human Blood Monocyte-derived Dendritic Cells and Macrophages Reveal miR-511 as Putative Positive Regulator of Toll-like Receptor 4
L. Tserel, T. Runnel, K. Kisand, M. Pihlap, L. Bakhoff, R. Kolde, H. Peterson, J. Vilo, P. Peterson, A. Rebane et al.
J Biol Chem 286, 26487-26495 (29 July 2011)

Porphyromonas gingivalis Induction of MicroRNA-203 Expression Controls Suppressor of Cytokine Signaling 3 in Gingival Epithelial Cells
C. E. Moffatt, and R. J. Lamont
Infect. Immun. 79, 2632-2637 (1 July 2011)

MicroRNAs in Development and Disease
D. Sayed, and M. Abdellatif
Physiol. Rev. 91, 827-887 (1 July 2011)

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882