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Putting the Brakes on Regeneration

Science, 7 June 2002
Vol. 296, Issue 5574, p. 1819-1820
DOI: 10.1126/science.1073590

Putting the Brakes on Regeneration

  1. Lisa McKerracher,
  2. Benjamin Ellezam*
  1. The authors are in the Département de Pathologie et Biologie Cellulaire, Université de Montréal, 2900 Edouard-Montpetit, Montréal, Québec, H3T 1J4 Canada. E-mail: mckerral{at}


The recalcitrance of nerves in the central nervous system (CNS) to regenerate has thwarted efforts to treat patients with spinal cord and other CNS injuries. In their Perspective, McKerracher and Ellezam discuss new findings ( Goldberg et al.) revealing that a switch from an axonal to a dendritic growth mode during development may carry over into the adult, preventing CNS neurons from regenerating their axons.


L. McKerracher and B. Ellezam, Putting the Brakes on Regeneration. Science 296, 1819-1820 (2002).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882