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History Matters

Science, 9 August 2002
Vol. 297, Issue 5583, p. 948-949
DOI: 10.1126/science.1075222

History Matters

  1. Nicholas T. Ingolia,
  2. Andrew W. Murray*
  1. The authors are in the Department of Molecular and Cellular Biology and Bauer Center for Genomics Research, Harvard University, Cambridge, MA 02138, USA. E-mail: amurray{at}mcb.harvard.edu

Summary

How do signaling networks within cells communicate with each other in order to respond to a vast array of external stimuli with the correct responses? In their Perspective, Ingolia and Murray discuss a new approach (Bhalla et al.) that elucidates the regulation of the MAPK signaling cascade in cultured cells and how cellular history contributes to this regulation.

Citation:

N. T. Ingolia and A. W. Murray, History Matters. Science 297, 948-949 (2002).

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