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Inhibition of Neuroepithelial Patched-Induced Apoptosis by Sonic Hedgehog

Science, 8 August 2003
Vol. 301, Issue 5634, p. 843-846
DOI: 10.1126/science.1085405

Inhibition of Neuroepithelial Patched-Induced Apoptosis by Sonic Hedgehog

  1. Chantal Thibert1,
  2. Marie-Aimée Teillet2,
  3. Françoise Lapointe2,
  4. Laetitia Mazelin1,
  5. Nicole M. Le Douarin2,
  6. Patrick Mehlen1,3,*
  1. 1 Apoptosis/Differentiation Laboratory, “La Ligue,” Molecular and Cellular Genetic Center, CNRS Unite Mixte Recherche (UMR) 5534, University of Lyon, 69622 Villeurbanne, France.
  2. 2 Laboratoire d'Embryologie Cellulaire et Moléculaire, CNRS UMR 7128, 49 bis, Avenue de la Belle-Gabrielle, 94736 Nogent-sur-Marne Cedex, France.
  3. 3 International Agency for Research in Cancer, 69008 Lyon, France.
  1. * To whom correspondence should be addressed. E-mail: mehlen{at}univ-lyon1.fr

Abstract

During early development in vertebrates, Sonic hedgehog (Shh) is produced by the notochord and the floor plate. A ventrodorsal gradient of Shh directs ventrodorsal patterning of the neural tube. However, Shh is also required for the survival of neuroepithelial cells. We show that Patched (Ptc) induces apoptotic cell death unless its ligand Shh is present to block the signal. Moreover, the blockade of Ptc-induced cell death partly rescues the chick spinal cord defect provoked by Shh deprivation. Thus, the proapoptotic activity of unbound Ptc and the positive effect of Shh-bound Ptc on cell differentiation probably cooperate to achieve the appropriate spinal cord development.

  • Received for publication 7 April 2003.
  • Accepted for publication 18 June 2003.

Citation:

C. Thibert, M.-A. Teillet, F. Lapointe, L. Mazelin, N. M. Le Douarin, and P. Mehlen, Inhibition of Neuroepithelial Patched-Induced Apoptosis by Sonic Hedgehog. Science 301, 843-846 (2003).

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