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Tubulogenesis CLICs into Place

Science, 19 December 2003
Vol. 302, Issue 5653, p. 2077-2078
DOI: 10.1126/science.1093203

Tubulogenesis CLICs into Place

  1. Sarah M. Paul,
  2. Greg J. Beitel*
  1. The authors are in the Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA. E-mail: beitel{at}


Organs such as the kidney and vascular system have tubes as their functional units. Vital though such tubes are, little is known about how they are formed during embryonic development. In their Perspective, Paul and Beitel discuss new work in the worm ( Berry et al.) demonstrating that an intracellular chloride channel protein called EXC-4 is required for tube formation.


S. M. Paul and G. J. Beitel, Tubulogenesis CLICs into Place. Science 302, 2077-2078 (2003).

Unexpected Roles of the Na-K-ATPase and Other Ion Transporters in Cell Junctions and Tubulogenesis
T. Krupinski, and G. J. Beitel
Physiology 24, 192-201 (1 June 2009)

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882