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A Pattern of Precision

Science, 30 January 2004
Vol. 303, Issue 5658, p. 637-638
DOI: 10.1126/science.1094409

A Pattern of Precision

  1. Paul W. Sternberg*
  1. The author is at the Howard Hughes Medical Institute and Division of Biology 156-29, California Institute of Technology, Pasadena, CA 91125, USA. E-mail: pws{at}


The nematode is a simple organism that has proved invaluable for studying cell fate decisions during development. In his Perspective, Sternberg discusses new work ( Yoo et al. ) showing that cooperation between the EGF and LIN-12 signaling pathways determines the fates adopted by vulval precursor cells during vulval development in the nematode.


P. W. Sternberg, A Pattern of Precision. Science 303, 637-638 (2004).

Computational insights into Caenorhabditis elegans vulval development
J. Fisher, N. Piterman, E. J. A. Hubbard, M. J. Stern, and D. Harel
Proc. Natl. Acad. Sci. USA 102, 1951-1956 (8 February 2005)

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882