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Recycling Endosomes Supply AMPA Receptors for LTP

Science, 24 September 2004
Vol. 305, Issue 5692, p. 1972-1975
DOI: 10.1126/science.1102026

Recycling Endosomes Supply AMPA Receptors for LTP

  1. Mikyoung Park1,*,
  2. Esther C. Penick3,*,
  3. Jeffrey G. Edwards3,
  4. Julie A. Kauer3,
  5. Michael D. Ehlers1,2,
  1. 1 Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA.
  2. 2 Department of Cell Biology, Department of Pharmacology and Cancer Biology, Department of Pathology, and Neuroproteomics Laboratory; Duke University Medical Center, Box 3209, Durham, NC 27710, USA.
  3. 3 Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA.
  1. To whom correspondence should be addressed. E-mail: ehlers{at}
  • * These authors contributed equally to this work.


Long-term potentiation (LTP) of synaptic strength, the most established cellular model of information storage in the brain, is expressed by an increase in the number of postsynaptic AMPA receptors. However, the source of AMPA receptors mobilized during LTP is unknown. We report that AMPA receptors are transported from recycling endosomes to the plasma membrane for LTP. Stimuli that triggered LTP promoted not only AMPA receptor insertion but also generalized recycling of cargo and membrane from endocytic compartments. Thus, recycling endosomes supply AMPA receptors for LTP and provide a mechanistic link between synaptic potentiation and membrane remodeling during synapse modification.

    • Received for publication 28 June 2004.
    • Accepted for publication 6 August 2004.


    M. Park, E. C. Penick, J. G. Edwards, J. A. Kauer, and M. D. Ehlers, Recycling Endosomes Supply AMPA Receptors for LTP. Science 305, 1972-1975 (2004).

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    Y.-N. Wang, L. Zhou, Y.-H. Li, Z. Wang, Y.-C. Li, Y.-W. Zhang, Y. Wang, G. Liu, and Y. Shen
    J. Neurosci. 35, 6429-6443 (22 April 2015)

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    JCB 208, 791-806 (16 March 2015)

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    G. Garcia-Alvarez, B. Lu, K. A. F. Yap, L. C. Wong, J. V. Thevathasan, L. Lim, F. Ji, K. W. Tan, J. J. Mancuso, W. Tang et al.
    Mol. Biol. Cell 26, 1141-1159 (15 March 2015)

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    R. A. Sarabdjitsingh, J. Jezequel, N. Pasricha, L. Mikasova, A. Kerkhofs, H. Karst, L. Groc, and M. Joels
    Proc. Natl. Acad. Sci. USA 111, 14265-14270 (30 September 2014)

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    D. Jullie, D. Choquet, and D. Perrais
    J. Neurosci. 34, 11106-11118 (13 August 2014)

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    N. K. Hussain, G. H. Diering, J. Sole, V. Anggono, and R. L. Huganir
    Proc. Natl. Acad. Sci. USA 111, 11840-11845 (12 August 2014)

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    J Biol Chem 289, 20773-20787 (25 July 2014)

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    A. Nakano-Kobayashi, Y. Tai, N. Nadif Kasri, and L. Van Aelst
    J. Neurosci. 34, 8665-8671 (25 June 2014)

    LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes
    T. Takano, T. Urushibara, N. Yoshioka, T. Saito, M. Fukuda, M. Tomomura, and S.-i. Hisanaga
    Mol. Biol. Cell 25, 1755-1768 (1 June 2014)

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    J. P. Dupuis, L. Ladepeche, H. Seth, L. Bard, J. Varela, L. Mikasova, D. Bouchet, V. Rogemond, J. Honnorat, E. Hanse et al.
    EMBO J. 33, 842-861 (16 April 2014)

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    S. Kantamneni, I. M. Gonzalez-Gonzalez, J. Luo, H. Cimarosti, S. C. Jacobs, N. Jaafari, and J. M. Henley
    J Biol Chem 289, 6681-6694 (7 March 2014)

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    C. E. J. Cheetham, S. J. Barnes, G. Albieri, G. W. Knott, and G. T. Finnerty
    Cereb Cortex 24, 521-531 (1 February 2014)

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    L. F. Ribeiro, T. Catarino, S. D. Santos, M. Benoist, J. F. van Leeuwen, J. A. Esteban, and A. L. Carvalho
    Proc. Natl. Acad. Sci. USA 111, E149-E158 (7 January 2014)

    Moderate AMPA receptor clustering on the nanoscale can efficiently potentiate synaptic current
    L. P. Savtchenko, and D. A. Rusakov
    Phil Trans R Soc B 369, 20130167-20130167 (2 December 2013)

    Dendritic trafficking for neuronal growth and plasticity
    M. D. Ehlers, and D. A. Rusakov
    Biochm. Soc. Trans. 41, 1365-1382 (1 December 2013)

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    S. Loebrich, B. Djukic, Z. J. Tong, J. R. Cottrell, G. G. Turrigiano, and E. Nedivi
    Proc. Natl. Acad. Sci. USA 110, E4548-E4556 (19 November 2013)

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    N. Vitureira, and Y. Goda
    JCB 203, 175-186 (28 October 2013)

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    J. A. Hammer, and W. Wagner
    J Biol Chem 288, 28428-28434 (4 October 2013)

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    T. E. Graber, P. K. McCamphill, and W. S. Sossin
    Learn. Mem. 20, 518-530 (16 September 2013)

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    V. Anggono, Y. Koc-Schmitz, J. Widagdo, J. Kormann, A. Quan, C.-M. Chen, P. J. Robinson, S.-Y. Choi, D. J. Linden, M. Plomann et al.
    Proc. Natl. Acad. Sci. USA 110, 13976-13981 (20 August 2013)

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    W. C. Hong, and S. G. Amara
    FASEB J. 27, 2995-3007 (1 August 2013)

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    X.-l. Zhang, B. Poschel, C. Faul, C. Upreti, P. K. Stanton, and P. Mundel
    J. Neurosci. 33, 12510-12518 (24 July 2013)

    Ral mediates activity-dependent growth of postsynaptic membranes via recruitment of the exocyst
    R. O. Teodoro, G. Pekkurnaz, A. Nasser, M. E. Higashi-Kovtun, M. Balakireva, I. G. McLachlan, J. Camonis, and T. L. Schwarz
    EMBO J. 32, 2039-2055 (17 July 2013)

    Shank3-Rich2 Interaction Regulates AMPA Receptor Recycling and Synaptic Long-Term Potentiation
    F. Raynaud, A. Janossy, J. Dahl, F. Bertaso, J. Perroy, A. Varrault, M. Vidal, P. F. Worley, T. M. Boeckers, J. Bockaert et al.
    J. Neurosci. 33, 9699-9715 (5 June 2013)

    Cooperation of MICAL-L1, syndapin2, and phosphatidic acid in tubular recycling endosome biogenesis
    S. S. P. Giridharan, B. Cai, N. Vitale, N. Naslavsky, and S. Caplan
    Mol. Biol. Cell 24, 1776-1790 (1 June 2013)

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    S.-H. Huang, J. Wang, W.-H. Sui, B. Chen, X.-Y. Zhang, J. Yan, Z. Geng, and Z.-Y. Chen
    J. Neurosci. 33, 9214-9230 (22 May 2013)

    Kainate Receptor Post-translational Modifications Differentially Regulate Association with 4.1N to Control Activity-dependent Receptor Endocytosis
    B. A. Copits, and G. T. Swanson
    J Biol Chem 288, 8952-8965 (29 March 2013)

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    E. C. Deane, A. E. Ilie, S. Sizdahkhani, M. Das Gupta, J. Orlowski, and R. A. McKinney
    J. Neurosci. 33, 595-610 (9 January 2013)

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    T. Liebmann, M. Kruusmagi, N. Sourial-Bassillious, A. Bondar, P. Svenningsson, M. Flajolet, P. Greengard, L. Scott, H. Brismar, A. Aperia et al.
    J. Neurosci. 32, 17998-18008 (12 December 2012)

    Studying Signal Transduction in Single Dendritic Spines
    R. Yasuda, M. Kruusmagi, N. Sourial-Bassillious, A. Bondar, P. Svenningsson, M. Flajolet, P. Greengard, L. Scott, H. Brismar, A. Aperia et al.
    Cold Spring Harb. Perspect. Biol. 4, a005611-a005611 (1 October 2012)

    The Balance between Receptor Recycling and Trafficking toward Lysosomes Determines Synaptic Strength during Long-Term Depression
    M. Fernandez-Monreal, T. C. Brown, M. Royo, and J. A. Esteban
    J. Neurosci. 32, 13200-13205 (19 September 2012)

    PICK1 Mediates Transient Synaptic Expression of GluA2-Lacking AMPA Receptors during Glycine-Induced AMPA Receptor Trafficking
    N. Jaafari, J. M. Henley, and J. G. Hanley
    J. Neurosci. 32, 11618-11630 (22 August 2012)

    Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability
    E. Moutin, F. Raynaud, J. Roger, E. Pellegrino, V. Homburger, F. Bertaso, V. Ollendorff, J. Bockaert, L. Fagni, J. Perroy et al.
    JCB 198, 251-263 (23 July 2012)

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    M. Mayford, S. A. Siegelbaum, and E. R. Kandel
    Cold Spring Harb. Perspect. Biol. 4, a005751-a005751 (1 June 2012)

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    S. Jurado, and S. Knafo
    J. Neurosci. 32, 7103-7105 (23 May 2012)

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    Y. Li, B. D. Roy, W. Wang, L. Zhang, L. Zhang, S. B. Sampson, Y. Yang, and D.-T. Lin
    J. Neurosci. 32, 7178-7190 (23 May 2012)

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    D. J. Keith, J. L. Sanderson, E. S. Gibson, K. M. Woolfrey, H. R. Robertson, K. Olszewski, R. Kang, A. El-Husseini, and M. L. Dell'Acqua
    J. Neurosci. 32, 7119-7136 (23 May 2012)

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    H. Kamiya, J. L. Sanderson, E. S. Gibson, K. M. Woolfrey, H. R. Robertson, K. Olszewski, R. Kang, A. El-Husseini, and M. L. Dell'Acqua
    J. Neurosci. 32, 6517-6524 (9 May 2012)

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    L. Mikasova, P. De Rossi, D. Bouchet, F. Georges, V. Rogemond, A. Didelot, C. Meissirel, J. Honnorat, and L. Groc
    Brain 135, 1606-1621 (1 May 2012)

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    C. Dean, F. M. Dunning, H. Liu, E. Bomba-Warczak, H. Martens, V. Bharat, S. Ahmed, and E. R. Chapman
    Mol. Biol. Cell 23, 1715-1727 (1 May 2012)

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    J Biol Chem 287, 12293-12308 (6 April 2012)

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    Y. Mori, T. Matsui, Y. Furutani, Y. Yoshihara, and M. Fukuda
    J Biol Chem 287, 8963-8973 (16 March 2012)

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    D. Zhang, N. R. Isack, D. R. Glodowski, J. Liu, C. C.-H. Chen, X. Z. S. Xu, B. D. Grant, and C. Rongo
    JCB 196, 85-101 (9 January 2012)

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    V. M. Ho, J.-A. Lee, and K. C. Martin
    Science 334, 623-628 (4 November 2011)

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    D. Puchkov, I. Leshchyns'ka, A. G. Nikonenko, M. Schachner, and V. Sytnyk
    Cereb Cortex 21, 2217-2232 (1 October 2011)

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    D. Richter, B. Katz, T. Oberacker, V. Tzarfaty, G. Belusic, B. Minke, and A. Huber
    J Biol Chem 286, 34234-34243 (30 September 2011)

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    J. Neurosci. 31, 8194-8209 (1 June 2011)

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    J. Greaves, J. A. Carmichael, and L. H. Chamberlain
    Mol. Biol. Cell 22, 1887-1895 (1 June 2011)

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    J.-H. Tao-Cheng, V. T. Crocker, C. A. Winters, R. Azzam, J. Chludzinski, and T. S. Reese
    J. Neurosci. 31, 4834-4843 (30 March 2011)

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    J Biol Chem 286, 7379-7388 (4 March 2011)

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    J. Neurosci. 31, 3077-3081 (23 February 2011)

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    S. Jurgensen, L. L. Antonio, G. E. A. Mussi, J. Brito-Moreira, T. R. Bomfim, F. G. De Felice, E. R. Garrido-Sanabria, E. A. Cavalheiro, and S. T. Ferreira
    J Biol Chem 286, 3270-3276 (4 February 2011)

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    Neuroscientist 17, 54-78 (1 February 2011)

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    J. R. Kowalski, C. L. Dahlberg, and P. Juo
    J. Neurosci. 31, 1341-1354 (26 January 2011)

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    L. Fourgeaud, C. M. Davenport, C. M. Tyler, T. T. Cheng, M. B. Spencer, and L. M. Boulanger
    Proc. Natl. Acad. Sci. USA 107, 22278-22283 (21 December 2010)

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    Z. M. Lasiecka, C. C. Yap, S. Caplan, and B. Winckler
    J. Neurosci. 30, 16485-16497 (8 December 2010)

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    Sci Signal 3, jc7-jc7 (19 October 2010)

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    M. J. Naughtin, D. A. Sheffield, P. Rahman, W. E. Hughes, R. Gurung, J. L. Stow, H. H. Nandurkar, J. M. Dyson, and C. A. Mitchell
    J. Cell Sci. 123, 3071-3083 (15 September 2010)

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    I. Martinez-Pena y Valenzuela, C. Mouslim, and M. Akaaboune
    J. Neurosci. 30, 12455-12465 (15 September 2010)

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    M. A. Patterson, E. M. Szatmari, and R. Yasuda
    Proc. Natl. Acad. Sci. USA 107, 15951-15956 (7 September 2010)

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    M. T. Lin, R. Lujan, M. Watanabe, M. Frerking, J. Maylie, and J. P. Adelman
    J. Neurosci. 30, 11726-11734 (1 September 2010)

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    R. Eva, E. Dassie, P. T. Caswell, G. Dick, C. ffrench-Constant, J. C. Norman, and J. W. Fawcett
    J. Neurosci. 30, 11654-11669 (1 September 2010)

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    J. Wei, W. Liu, and Z. Yan
    J Biol Chem 285, 26369-26376 (20 August 2010)

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    O. Bozdagi, X.-b. Wang, J. S. Nikitczuk, T. R. Anderson, E. B. Bloss, G. L. Radice, Q. Zhou, D. L. Benson, and G. W. Huntley
    J. Neurosci. 30, 9984-9989 (28 July 2010)

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    Y. Yang, X.-b. Wang, and Q. Zhou
    Proc. Natl. Acad. Sci. USA 107, 11999-12004 (29 June 2010)

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    Y. Araki, D.-T. Lin, and R. L. Huganir
    Proc. Natl. Acad. Sci. USA 107, 11080-11085 (15 June 2010)

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    Z.-J. Tan, Y. Peng, H.-L. Song, J.-J. Zheng, and X. Yu
    Proc. Natl. Acad. Sci. USA 107, 9873-9878 (25 May 2010)

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    P. Hotulainen, and C. C. Hoogenraad
    JCB 189, 619-629 (17 May 2010)

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    C. C. C. Yap, Z. M. Lasiecka, S. Caplan, and B. Winckler
    J. Neurosci. 30, 6646-6657 (12 May 2010)

    Endosomal sorting of AMPA receptors in hippocampal neurons
    J. G. Hanley, Z. M. Lasiecka, S. Caplan, and B. Winckler
    Biochm. Soc. Trans. 38, 460-465 (1 April 2010)

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    X. Li, A. Valencia, E. Sapp, N. Masso, J. Alexander, P. Reeves, K. B. Kegel, N. Aronin, and M. DiFiglia
    J. Neurosci. 30, 4552-4561 (31 March 2010)

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    W. Liu, E. Y. Yuen, and Z. Yan
    J Biol Chem 285, 6101-6108 (26 February 2010)

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    N. F. Shanks, T. Maruo, A. N. Farina, M. H. Ellisman, and T. Nakagawa
    J. Neurosci. 30, 2728-2740 (17 February 2010)

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    S. Feliciangeli, M. P. Tardy, G. Sandoz, F. C. Chatelain, R. Warth, J. Barhanin, S. Bendahhou, and F. Lesage
    J Biol Chem 285, 4798-4805 (12 February 2010)

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    C. G. Lau, Y. Takayasu, A. Rodenas-Ruano, A. V. Paternain, J. Lerma, M. V. L. Bennett, and R. S. Zukin
    J. Neurosci. 30, 242-254 (6 January 2010)

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    I. Saez, and M. J. Friedlander
    J. Neurosci. 29, 15286-15298 (2 December 2009)

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    M.-F. Lise, D. P. Srivastava, P. Arstikaitis, R. L. Lett, R. Sheta, V. Viswanathan, P. Penzes, T. P. O'Connor, and A. El-Husseini
    J. Cell Sci. 122, 3810-3821 (15 October 2009)

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    I. L. Arancibia-Carcamo, E. Y. Yuen, J. Muir, M. J. Lumb, G. Michels, R. S. Saliba, T. G. Smart, Z. Yan, J. T. Kittler, S. J. Moss et al.
    Proc. Natl. Acad. Sci. USA 106, 17552-17557 (13 October 2009)

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    Y. Yang, and Q. Zhou
    Neuroscientist 15, 464-476 (1 October 2009)

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    M. Ascano, A. Richmond, P. Borden, and R. Kuruvilla
    J. Neurosci. 29, 11674-11685 (16 September 2009)

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    L. Zhao, A.-L. Sheng, S.-H. Huang, Y.-X. Yin, B. Chen, X.-Z. Li, Y. Zhang, and Z.-Y. Chen
    J. Cell Sci. 122, 3123-3136 (1 September 2009)

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    M. M. Gorska, Q. Liang, Z. Karim, and R. Alam
    J. Immunol. 183, 1675-1684 (1 August 2009)

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    H. R. Robertson, E. S. Gibson, T. A. Benke, and M. L. Dell''Acqua
    J. Neurosci. 29, 7929-7943 (17 June 2009)

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    M. Jovic, F. Kieken, N. Naslavsky, P. L. Sorgen, and S. Caplan
    Mol. Biol. Cell 20, 2731-2743 (1 June 2009)

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    H. Sugiura, H. Tanaka, S. Yasuda, T. Takemiya, and K. Yamagata
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    Monomeric IgG Is Neuroprotective via Enhancing Microglial Recycling Endocytosis and TNF-{alpha}
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