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Recycling Endosomes Supply AMPA Receptors for LTP

Science, 24 September 2004
Vol. 305, Issue 5692, p. 1972-1975
DOI: 10.1126/science.1102026

Recycling Endosomes Supply AMPA Receptors for LTP

  1. Mikyoung Park1,*,
  2. Esther C. Penick3,*,
  3. Jeffrey G. Edwards3,
  4. Julie A. Kauer3,
  5. Michael D. Ehlers1,2,
  1. 1 Department of Neurobiology, Duke University Medical Center, Box 3209, Durham, NC 27710, USA.
  2. 2 Department of Cell Biology, Department of Pharmacology and Cancer Biology, Department of Pathology, and Neuroproteomics Laboratory; Duke University Medical Center, Box 3209, Durham, NC 27710, USA.
  3. 3 Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA.
  1. To whom correspondence should be addressed. E-mail: ehlers{at}neuro.duke.edu
  • * These authors contributed equally to this work.

Abstract

Long-term potentiation (LTP) of synaptic strength, the most established cellular model of information storage in the brain, is expressed by an increase in the number of postsynaptic AMPA receptors. However, the source of AMPA receptors mobilized during LTP is unknown. We report that AMPA receptors are transported from recycling endosomes to the plasma membrane for LTP. Stimuli that triggered LTP promoted not only AMPA receptor insertion but also generalized recycling of cargo and membrane from endocytic compartments. Thus, recycling endosomes supply AMPA receptors for LTP and provide a mechanistic link between synaptic potentiation and membrane remodeling during synapse modification.

    • Received for publication 28 June 2004.
    • Accepted for publication 6 August 2004.

    Citation:

    M. Park, E. C. Penick, J. G. Edwards, J. A. Kauer, and M. D. Ehlers, Recycling Endosomes Supply AMPA Receptors for LTP. Science 305, 1972-1975 (2004).

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