Error message

No crossref credentials set for sci

Natural Killer Cell Signaling Pathways

Science, 26 November 2004
Vol. 306, Issue 5701, p. 1517-1519
DOI: 10.1126/science.1103478

Natural Killer Cell Signaling Pathways

  1. Eric Vivier1,*,
  2. Jacques A. Nunès2,
  3. Frédéric Vély3
  1. 1 Centre d'Immunologie de Marseille-Luminy, INSERM–CNRS–Univ. Méditerranée, Campus de Luminy, Case 906, 13288 Marseille cedex 09, France.
  2. 2 Institut de Cancérologie de Marseille, INSERM UMR 599, 13009 Marseille, France.
  3. 3 INSERM U608-Univ. Méditerranée, Faculté de Pharmacie, 13005 Marseille, France.
  1. * To whom correspondence should be addressed. E-mail: vivier{at}ciml.univ-mrs.fr

Abstract

Natural killer (NK) cells are lymphocytes of the innate immune system that are involved in the early defenses against foreign cells, as well as autologous cells undergoing various forms of stress, such as microbial infection or tumor transformation. NK cell activation is controlled by a dynamic balance between complementary and antagonistic pathways that are initiated upon interaction with potential target cells. NK cells express an array of activating cell surface receptors that can trigger cytolytic programs, as well as cytokine or chemokine secretion. Some of these activating cell surface receptors initiate protein tyrosine kinase (PTK)–dependent pathways through noncovalent associations with transmembrane signaling adaptors that harbor intracytoplasmic ITAMs (immunoreceptor tyrosine-based activation motifs). Additional cell surface receptors that are not directly coupled to ITAMs also participate in NK cell activation. These include NKG2D, which is noncovalently associated to the DAP10 transmembrane signaling adaptor, as well as integrins and cytokine receptors. NK cells also express cell surface inhibitory receptors that antagonize activating pathways through protein tyrosine phosphatases (PTPs). These inhibitory cell surface receptors are characterized by intracytoplasmic ITIMs (immunoreceptor tyrosine-based inhibition motifs). The tyrosine-phosphorylation status of several signaling components that are substrates for both PTKs and PTPs is thus key to the propagation of the NK cell effector pathways. Understanding the integration of these multiple signals is central to the understanding and manipulation of NK cell effector signaling pathways.

Citation:

E. Vivier, J. A. Nunès, and F. Vély, Natural Killer Cell Signaling Pathways. Science 306, 1517-1519 (2004).

CD160 is essential for NK-mediated IFN-{gamma} production
T. C. Tu, N. K. Brown, T.-J. Kim, J. Wroblewska, X. Yang, X. Guo, S. H. Lee, V. Kumar, K.-M. Lee, Y.-X. Fu et al.
JEM 212, 415-429 (9 March 2015)

Activation-Specific Metabolic Requirements for NK Cell IFN-{gamma} Production
M. P. Keppel, N. Saucier, A. Y. Mah, T. P. Vogel, and M. A. Cooper
J. Immunol. 194, 1954-1962 (15 February 2015)

Afucosylated Antibodies Increase Activation of Fc{gamma}RIIIa-Dependent Signaling Components to Intensify Processes Promoting ADCC
S. D. Liu, C. Chalouni, J. C. Young, T. T. Junttila, M. X. Sliwkowski, and J. B. Lowe
Cancer Immunol Res 3, 173-183 (1 February 2015)

NK cells kill mycobacteria directly by releasing perforin and granulysin
C.-C. Lu, T.-S. Wu, Y.-J. Hsu, C.-J. Chang, C.-S. Lin, J.-H. Chia, T.-L. Wu, T.-T. Huang, J. Martel, D. M. Ojcius et al.
J. Leukoc. Biol. 96, 1119-1129 (1 December 2014)

Immunoglobulin-like transcripts 6 (ILT6) polymorphism influences the anti-Ro60/52 autoantibody status in south Indian SLE patients
P. Devaraju, T. Witte, R. Schmidt, R. Gulati, and V. Negi
Lupus 23, 1149-1155 (1 October 2014)

Dok1 and Dok2 proteins regulate natural killer cell development and function
J. Celis-Gutierrez, M. Boyron, T. Walzer, P. P. Pandolfi, S. Jonjic, D. Olive, M. Dalod, E. Vivier, and J. A. Nunes
EMBO J. 33, 1928-1940 (1 September 2014)

A Think Tank of TINK/TANKs: Tumor-Infiltrating/Tumor-Associated Natural Killer Cells in Tumor Progression and Angiogenesis
A. Bruno, G. Ferlazzo, A. Albini, and D. M. Noonan
JNCI J Natl Cancer Inst 106, dju200-dju200 (1 August 2014)

Recognition of adult and pediatric acute lymphoblastic leukemia blasts by natural killer cells
G. F. Torelli, N. Peragine, S. Raponi, D. Pagliara, M. S. De Propris, A. Vitale, A. Bertaina, W. Barberi, L. Moretta, G. Basso et al.
haematol 99, 1248-1254 (1 July 2014)

N6-isopentenyladenosine, an endogenous isoprenoid end product, directly affects cytotoxic and regulatory functions of human NK cells through FDPS modulation
E. Ciaglia, S. Pisanti, P. Picardi, C. Laezza, A. M. Malfitano, A. D'Alessandro, P. Gazzerro, M. Vitale, E. Carbone, M. Bifulco et al.
J. Leukoc. Biol. 94, 1207-1219 (1 December 2013)

Hepatitis C Virus-Infected Cells Downregulate NKp30 and Inhibit Ex Vivo NK Cell Functions
K. A. Holder, S. N. Stapleton, M. E. Gallant, R. S. Russell, and M. D. Grant
J. Immunol. 191, 3308-3318 (15 September 2013)

Superresolution Microscopy Reveals Nanometer-Scale Reorganization of Inhibitory Natural Killer Cell Receptors upon Activation of NKG2D
S. V. Pageon, S.-P. Cordoba, D. M. Owen, S. M. Rothery, A. Oszmiana, and D. M. Davis
Sci Signal 6, ra62-ra62 (23 July 2013)

NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)
R. Romee, B. Foley, T. Lenvik, Y. Wang, B. Zhang, D. Ankarlo, X. Luo, S. Cooley, M. Verneris, B. Walcheck et al.
Blood 121, 3599-3608 (2 May 2013)

Murine natural killer cell licensing and regulation by T regulatory cells in viral responses
C. M. Sungur, Y. J. Tang-Feldman, E. Ames, M. Alvarez, M. Chen, D. L. Longo, C. Pomeroy, and W. J. Murphy
Proc. Natl. Acad. Sci. USA 110, 7401-7406 (30 April 2013)

TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors
R. J. W. Arts, L. A. B. Joosten, J. W. M. van der Meer, and M. G. Netea
J. Leukoc. Biol. 93, 209-215 (1 February 2013)

Bispecific and Trispecific Killer Cell Engagers Directly Activate Human NK Cells through CD16 Signaling and Induce Cytotoxicity and Cytokine Production
M. K. Gleason, M. R. Verneris, D. A. Todhunter, B. Zhang, V. McCullar, S. X. Zhou, A. Panoskaltsis-Mortari, L. M. Weiner, D. A. Vallera, J. S. Miller et al.
Molecular Cancer Therapeutics 11, 2674-2684 (1 December 2012)

Whole blood genome-wide gene expression profile in males after prolonged wakefulness and sleep recovery
R. Pellegrino, D. Y. Sunaga, C. Guindalini, R. C. S. Martins, D. R. Mazzotti, Z. Wei, Z. J. Daye, M. L. Andersen, and S. Tufik
Physiol. Genomics 44, 1003-1012 (1 November 2012)

The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma
J. Wu, J. Li, R. Salcedo, N. F. Mivechi, G. Trinchieri, and A. Horuzsko
Cancer Res. 72, 3977-3986 (15 August 2012)

Natural Killer Cell Tolerance: Control by Self or Self-Control?
B. N. Jaeger, and E. Vivier
Cold Spring Harb. Perspect. Biol. 4, a007229-a007229 (1 March 2012)

Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity
P. A. Lang, K. S. Lang, H. C. Xu, M. Grusdat, I. A. Parish, M. Recher, A. R. Elford, S. Dhanji, N. Shaabani, C. W. Tran et al.
Proc. Natl. Acad. Sci. USA 109, 1210-1215 (24 January 2012)

Antibacterial Role for Natural Killer Cells in Host Defense to Bacillus anthracis
C. M. Gonzales, C. B. Williams, V. E. Calderon, M. B. Huante, S. T. Moen, V. L. Popov, W. B. Baze, J. W. Peterson, and J. J. Endsley
Infect. Immun. 80, 234-242 (1 January 2012)

Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor
E. Narni-Mancinelli, J. Chaix, A. Fenis, Y. M. Kerdiles, N. Yessaad, A. Reynders, C. Gregoire, H. Luche, S. Ugolini, E. Tomasello et al.
Proc. Natl. Acad. Sci. USA 108, 18324-18329 (8 November 2011)

Human mesenchymal stem cells derived from induced pluripotent stem cells down-regulate NK-cell cytolytic machinery
M. Giuliani, N. Oudrhiri, Z. M. Noman, A. Vernochet, S. Chouaib, B. Azzarone, A. Durrbach, and A. Bennaceur-Griscelli
Blood 118, 3254-3262 (22 September 2011)

NK cell education after allogeneic transplantation: dissociation between recovery of cytokine-producing and cytotoxic functions
B. Foley, S. Cooley, M. R. Verneris, J. Curtsinger, X. Luo, E. K. Waller, D. J. Weisdorf, and J. S. Miller
Blood 118, 2784-2792 (8 September 2011)

Simulations of the NK Cell Immune Synapse Reveal that Activation Thresholds Can Be Established by Inhibitory Receptors Acting Locally
A. Kaplan, S. Kotzer, C. R. Almeida, R. Kohen, G. Halpert, M. Salmon-Divon, K. Kohler, P. Hoglund, D. M. Davis, R. Mehr et al.
J. Immunol. 187, 760-773 (15 July 2011)

Inhibitory ITAM Signaling Traps Activating Receptors with the Phosphatase SHP-1 to Form Polarized "Inhibisome" Clusters
S. Pfirsch-Maisonnas, M. Aloulou, T. Xu, J. Claver, Y. Kanamaru, M. Tiwari, P. Launay, R. C. Monteiro, and U. Blank
Sci Signal 4, ra24-ra24 (19 April 2011)

Confinement of Activating Receptors at the Plasma Membrane Controls Natural Killer Cell Tolerance
S. Guia, B. N. Jaeger, S. Piatek, S. Mailfert, T. Trombik, A. Fenis, N. Chevrier, T. Walzer, Y. M. Kerdiles, D. Marguet et al.
Sci Signal 4, ra21-ra21 (5 April 2011)

Impact of {beta}2 integrin deficiency on mouse natural killer cell development and function
K. Crozat, C. Eidenschenk, B. N. Jaeger, P. Krebs, S. Guia, B. Beutler, E. Vivier, and S. Ugolini
Blood 117, 2874-2882 (10 March 2011)

Killer immunoglobulin-like receptors (KIRs) and HLA-C allorecognition patterns implicative of dominant activation of natural killer cells contribute to recurrent miscarriages
R. M. Faridi, and S. Agrawal
Hum Reprod 26, 491-497 (1 February 2011)

Innate or Adaptive Immunity? The Example of Natural Killer Cells
E. Vivier, D. H. Raulet, A. Moretta, M. A. Caligiuri, L. Zitvogel, L. L. Lanier, W. M. Yokoyama, and S. Ugolini
Science 331, 44-49 (7 January 2011)

Protective Efficacy of DNA Vaccines Encoding Outer Membrane Protein A and OmpK36 of Klebsiella pneumoniae in Mice
P. Kurupati, N. P. Ramachandran, and C. L. Poh
CVI 18, 82-88 (1 January 2011)

HIV inhibits early signal transduction events triggered by CD16 cross-linking on NK cells, which are important for antibody-dependent cellular cytotoxicity
G. F. Lichtfuss, A. C. Meehan, W.-J. Cheng, P. U. Cameron, S. R. Lewin, S. M. Crowe, and A. Jaworowski
J. Leukoc. Biol. 89, 149-158 (1 January 2011)

Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15R{alpha} complexes
K. G. Elpek, M. P. Rubinstein, A. Bellemare-Pelletier, A. W. Goldrath, and S. J. Turley
Proc. Natl. Acad. Sci. USA 107, 21647-21652 (14 December 2010)

Interaction between KIR3DS1 and HLA-Bw4 predicts for progression-free survival after autologous stem cell transplantation in patients with multiple myeloma
I. H. Gabriel, R. Sergeant, R. Szydlo, J. F. Apperley, H. deLavallade, A. Alsuliman, A. Khoder, D. Marin, E. Kanfer, N. Cooper et al.
Blood 116, 2033-2039 (23 September 2010)

Differential Activation of NK Cells by Influenza A Pseudotype H5N1 and 1918 and 2009 Pandemic H1N1 Viruses
N. Du, J. Zhou, X. Lin, Y. Zhang, X. Yang, Y. Wang, and Y. Shu
J. Virol. 84, 7822-7831 (1 August 2010)

Suppressor of Cytokine Signaling 2 Regulates IL-15-Primed Human NK Cell Function via Control of Phosphorylated Pyk2
S. H. Lee, S. Yun, Z.-H. Piao, M. Jeong, D. O. Kim, H. Jung, J. Lee, M. J. Kim, M. S. Kim, J. W. Chung et al.
J. Immunol. 185, 917-928 (15 July 2010)

RasGRP1 Is Required for Human NK Cell Function
S. H. Lee, S. Yun, J. Lee, M. J. Kim, Z.-H. Piao, M. Jeong, J. W. Chung, T.-D. Kim, S. R. Yoon, P. D. Greenberg et al.
J. Immunol. 183, 7931-7938 (15 December 2009)

Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases
B. Gao, S. Radaeva, and O. Park
J. Leukoc. Biol. 86, 513-528 (1 September 2009)

Essential role of the Ly49A stalk region for immunological synapse formation and signaling
D. Ito, Y.-M. Iizuka, M. P. Katepalli, and K. Iizuka
Proc. Natl. Acad. Sci. USA 106, 11264-11269 (7 July 2009)

Bromohydrin pyrophosphate enhances antibody-dependent cell-mediated cytotoxicity induced by therapeutic antibodies
J. Gertner-Dardenne, C. Bonnafous, C. Bezombes, A.-H. Capietto, V. Scaglione, S. Ingoure, D. Cendron, E. Gross, J.-F. Lepage, A. Quillet-Mary et al.
Blood 113, 4875-4884 (14 May 2009)

Creation of the two isoforms of rodent NKG2D was driven by a B1 retrotransposon insertion
C. B. Lai, Y. Zhang, S. L. Rogers, and D. L. Mager
Nucleic Acids Res 37, 3032-3043 (1 May 2009)

Oxidative Stress Mediates a Reduced Expression of the Activating Receptor NKG2D in NK Cells from End-Stage Renal Disease Patients
M.-N. Peraldi, J. Berrou, N. Dulphy, A. Seidowsky, P. Haas, N. Boissel, F. Metivier, C. Randoux, N. Kossari, A. Guerin et al.
J. Immunol. 182, 1696-1705 (1 February 2009)

Identification and Characterization of a Transmembrane Isoform of CD160 (CD160-TM), a Unique Activating Receptor Selectively Expressed upon Human NK Cell Activation
J. Giustiniani, A. Bensussan, and A. Marie-Cardine
J. Immunol. 182, 63-71 (1 January 2009)

NK cell-activating receptors require PKC-{theta} for sustained signaling, transcriptional activation, and IFN-{gamma} secretion
I. Tassi, M. Cella, R. Presti, A. Colucci, S. Gilfillan, D. R. Littman, and M. Colonna
Blood 112, 4109-4116 (15 November 2008)

Essential Role of DAP12 Signaling in Macrophage Programming into a Fusion-Competent State
L. Helming, E. Tomasello, T. R. Kyriakides, F. O. Martinez, T. Takai, S. Gordon, and E. Vivier
Sci Signal 1, ra11-ra11 (28 October 2008)

Inhibition of Mitogen-activated Protein Kinase Phosphatase 3 Activity by Interdomain Binding
J. K. Mark, R. A. Aubin, S. Smith, and M. A. Hefford
J Biol Chem 283, 28574-28583 (17 October 2008)

Human natural killer cells
M. A. Caligiuri, R. A. Aubin, S. Smith, and M. A. Hefford
Blood 112, 461-469 (1 August 2008)

Serum Supplementation Modulates the Effects of Dibutyltin on Human Natural Killer Cell Function
M. M. Whalen, J. C. DeWitt, and R. W. Luebke
Toxicol Sci 104, 312-319 (1 August 2008)

Cell Type-Specific Regulation of ITAM-Mediated NF-{kappa}B Activation by the Adaptors, CARMA1 and CARD9
H. Hara, C. Ishihara, A. Takeuchi, L. Xue, S. W. Morris, J. M. Penninger, H. Yoshida, and T. Saito
J. Immunol. 181, 918-930 (15 July 2008)

Dasatinib suppresses in vitro natural killer cell cytotoxicity
S. J. Blake, A. Bruce Lyons, C. K. Fraser, J. D. Hayball, and T. P. Hughes
Blood 111, 4415-4416 (15 April 2008)

Distinct regulatory functions of SLP-76 and MIST in NK cell cytotoxicity and IFN-{gamma} production
S. Hidano, H. Sasanuma, K. Ohshima, K.-i. Seino, L. Kumar, K. Hayashi, M. Hikida, T. Kurosaki, M. Taniguchi, R. S. Geha et al.
Int Immunol 20, 345-352 (1 March 2008)

JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity
C. Li, B. Ge, M. Nicotra, J. N. H. Stern, H. D. Kopcow, X. Chen, and J. L. Strominger
Proc. Natl. Acad. Sci. USA 105, 3017-3022 (26 February 2008)

WIP is essential for lytic granule polarization and NK cell cytotoxicity
K. Krzewski, X. Chen, and J. L. Strominger
Proc. Natl. Acad. Sci. USA 105, 2568-2573 (19 February 2008)

Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance
A. M. Unni, T. Bondar, and R. Medzhitov
Proc. Natl. Acad. Sci. USA 105, 1686-1691 (5 February 2008)

SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production
M. Cho, K. Ishida, J. Chen, J. Ohkawa, W. Chen, S. Namiki, A. Kotaki, N. Arai, K.-i. Arai, Y. Kamogawa-Schifter et al.
Int Immunol 20, 155-164 (1 January 2008)

EAE Tolerance Induction with Hsp70-Peptide Complexes Depends on H60 and NKG2D Activity
G. Galazka, A. Jurewicz, W. Orlowski, M. Stasiolek, C. F. Brosnan, C. S. Raine, and K. Selmaj
J. Immunol. 179, 4503-4512 (1 October 2007)

NK cytotoxicity mediated by CD16 but not by NKp30 is functional in Griscelli syndrome
R. Gazit, M. Aker, M. Elboim, H. Achdout, G. Katz, D. G. Wolf, S. Katzav, and O. Mandelboim
Blood 109, 4306-4312 (15 May 2007)

FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection
T. J. Wilson, R. M. Presti, I. Tassi, E. T. Overton, M. Cella, and M. Colonna
Blood 109, 3786-3793 (1 May 2007)

Disparity in IL-12 Release in Dendritic Cells and Macrophages in Response to Mycobacterium tuberculosis Is Due to Use of Distinct TLRs
L. Pompei, S. Jang, B. Zamlynny, S. Ravikumar, A. McBride, S. P. Hickman, and P. Salgame
J. Immunol. 178, 5192-5199 (15 April 2007)

Many NK cell receptors activate ERK2 and JNK1 to trigger microtubule organizing center and granule polarization and cytotoxicity
X. Chen, P. P. Trivedi, B. Ge, K. Krzewski, and J. L. Strominger
Proc. Natl. Acad. Sci. USA 104, 6329-6334 (10 April 2007)

CD160-activating NK cell effector functions depend on the phosphatidylinositol 3-kinase recruitment
M. Rabot, H. El Costa, B. Polgar, A. Marie-Cardine, M. Aguerre-Girr, A. Barakonyi, S. Valitutti, A. Bensussan, and P. Le Bouteiller
Int Immunol 19, 401-409 (1 April 2007)

Differential Regulation of Human NK Cell-Mediated Cytotoxicity by the Tyrosine Kinase Itk
D. Khurana, L. N. Arneson, R. A. Schoon, C. J. Dick, and P. J. Leibson
J. Immunol. 178, 3575-3582 (15 March 2007)

Dual Assemblies of an Activating Immune Receptor, MAIR-II, with ITAM-Bearing Adapters DAP12 and FcR{gamma} Chain on Peritoneal Macrophages
C. Nakahashi, S. Tahara-Hanaoka, N. Totsuka, Y. Okoshi, T. Takai, N. Ohkohchi, S.-i. Honda, K. Shibuya, and A. Shibuya
J. Immunol. 178, 765-770 (15 January 2007)

Segregation of HLA-C from ICAM-1 at NK Cell Immune Synapses Is Controlled by Its Cell Surface Density
C. R. Almeida, and D. M. Davis
J. Immunol. 177, 6904-6910 (15 November 2006)

Differential and Nonredundant Roles of Phospholipase C{gamma}2 and Phospholipase C{gamma}1 in the Terminal Maturation of NK Cells
J. Regunathan, Y. Chen, S. Kutlesa, X. Dai, L. Bai, R. Wen, D. Wang, and S. Malarkannan
J. Immunol. 177, 5365-5376 (15 October 2006)

Cutting Edge: TREM-2 Attenuates Macrophage Activation
I. R. Turnbull, S. Gilfillan, M. Cella, T. Aoshi, M. Miller, L. Piccio, M. Hernandez, and M. Colonna
J. Immunol. 177, 3520-3524 (15 September 2006)

Molecular and Functional Characterization of CD300b, a New Activating Immunoglobulin Receptor Able to Transduce Signals through Two Different Pathways
A. Martinez-Barriocanal, and J. Sayos
J. Immunol. 177, 2819-2830 (1 September 2006)

Vav1 Controls DAP10-Mediated Natural Cytotoxicity by Regulating Actin and Microtubule Dynamics
D. B. Graham, M. Cella, E. Giurisato, K. Fujikawa, A. V. Miletic, T. Kloeppel, K. Brim, T. Takai, A. S. Shaw, M. Colonna et al.
J. Immunol. 177, 2349-2355 (15 August 2006)

Nitric oxide inhibits exocytosis of cytolytic granules from lymphokine-activated killer cells
M. Ferlito, K. Irani, N. Faraday, and C. J. Lowenstein
Proc. Natl. Acad. Sci. USA 103, 11689-11694 (1 August 2006)

ADAP is dispensable for NK cell development and function
L. V. Fostel, J. Dluzniewska, Y. Shimizu, B. J. Burbach, and E. J. Peterson
Int Immunol 18, 1305-1314 (1 August 2006)

Microclusters of inhibitory killer immunoglobulin-like receptor signaling at natural killer cell immunological synapses
B. Treanor, P. M.P. Lanigan, S. Kumar, C. Dunsby, I. Munro, E. Auksorius, F. J. Culley, M. A. Purbhoo, D. Phillips, M. A.A. Neil et al.
JCB 174, 153-161 (3 July 2006)

Effects of adenylyl cyclase and protein kinase A inhibition on signaling enzymes in natural killer cells: comparison to tributyltin
M M Whalen, and S O Odman-Ghazi
Hum Exp Toxicol 25, 333-340 (1 June 2006)

Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12
A. L. Blasius, M. Cella, J. Maldonado, T. Takai, and M. Colonna
Blood 107, 2474-2476 (15 March 2006)

Multiplicity and plasticity of natural killer cell signaling pathways
S. Chiesa, M. Mingueneau, N. Fuseri, B. Malissen, D. H. Raulet, M. Malissen, E. Vivier, and E. Tomasello
Blood 107, 2364-2372 (15 March 2006)

A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2
K. Suzuki-Inoue, G. L. J. Fuller, A. Garcia, J. A. Eble, S. Pohlmann, O. Inoue, T. K. Gartner, S. C. Hughan, A. C. Pearce, G. D. Laing et al.
Blood 107, 542-549 (15 January 2006)

Silencing Human NKG2D, DAP10, and DAP12 Reduces Cytotoxicity of Activated CD8+ T Cells and NK Cells
M. Karimi, T. M. Cao, J. A. Baker, M. R. Verneris, L. Soares, and R. S. Negrin
J. Immunol. 175, 7819-7828 (15 December 2005)

The Cytotoxicity Receptor CRACC (CS-1) Recruits EAT-2 and Activates the PI3K and Phospholipase C{gamma} Signaling Pathways in Human NK Cells
I. Tassi, and M. Colonna
J. Immunol. 175, 7996-8002 (15 December 2005)

Heterogeneous Human NK Cell Responses to Plasmodium falciparum-Infected Erythrocytes
D. S. Korbel, K. C. Newman, C. R. Almeida, D. M. Davis, and E. M. Riley
J. Immunol. 175, 7466-7473 (1 December 2005)

CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-{beta}-dependent manner
F. Ghiringhelli, C. Menard, M. Terme, C. Flament, J. Taieb, N. Chaput, P. E. Puig, S. Novault, B. Escudier, E. Vivier et al.
JEM 202, 1075-1085 (17 October 2005)

Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44
A. Fuchs, M. Cella, T. Kondo, and M. Colonna
Blood 106, 2076-2082 (15 September 2005)

Recognition of peptide-MHC class I complexes by activating killer immunoglobulin-like receptors
C. A. Stewart, F. Laugier-Anfossi, F. Vely, X. Saulquin, J. Riedmuller, A. Tisserant, L. Gauthier, F. Romagne, G. Ferracci, F. A. Arosa et al.
Proc. Natl. Acad. Sci. USA 102, 13224-13229 (13 September 2005)

DAP12 (KARAP) amplifies inflammation and increases mortality from endotoxemia and septic peritonitis
I. R. Turnbull, J. E. McDunn, T. Takai, R. R. Townsend, J. P. Cobb, and M. Colonna
JEM 202, 363-369 (1 August 2005)

Phospholipase C-{gamma}2 Is a Critical Signaling Mediator for Murine NK Cell Activating Receptors
I. Tassi, R. Presti, S. Kim, W. M. Yokoyama, S. Gilfillan, and M. Colonna
J. Immunol. 175, 749-754 (15 July 2005)

Natural Killer Cell Receptor Signaling Pathway
F. Vely, and E. Vivier
Sci Signal 2005, cm6-cm6 (12 July 2005)

The Chicken Leukocyte Receptor Complex: A Highly Diverse Multigene Family Encoding at Least Six Structurally Distinct Receptor Types
B. C. Viertlboeck, F. A. Habermann, R. Schmitt, M. A. M. Groenen, L. Du Pasquier, and T. W. Gobel
J. Immunol. 175, 385-393 (1 July 2005)

New frontiers in immunology: Workshop on The Road Ahead: Future Directions in Fundamental and Clinical Immunology
B. Beutler, and J.-L. Casanova
EMBO Rep. 6, 620-623 (1 July 2005)

The Isoforms of Phospholipase C-{gamma} Are Differentially Used by Distinct Human NK Activating Receptors
J. L. Upshaw, R. A. Schoon, C. J. Dick, D. D. Billadeau, and P. J. Leibson
J. Immunol. 175, 213-218 (1 July 2005)

Natural selection drives recurrent formation of activating killer cell immunoglobulin-like receptor and Ly49 from inhibitory homologues
L. Abi-Rached, and P. Parham
JEM 201, 1319-1332 (18 April 2005)

Hierarchy of resistance to cervical neoplasia mediated by combinations of killer immunoglobulin-like receptor and human leukocyte antigen loci
M. Carrington, S. Wang, M. P. Martin, X. Gao, M. Schiffman, J. Cheng, R. Herrero, A. C. Rodriguez, R. Kurman, R. Mortel et al.
JEM 201, 1069-1075 (4 April 2005)

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882