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HIV: Experiencing the Pressures of Modern Life

Science, 4 March 2005
Vol. 307, Issue 5714, p. 1422-1424
DOI: 10.1126/science.1110009

HIV: Experiencing the Pressures of Modern Life

  1. David Nolan,
  2. Ian James,
  3. Simon Mallal*
  1. The authors are at the Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Western Australia 6000, Australia. E-mail: S.Mallal{at}


HIV/AIDS HIV, the wily virus that causes AIDS, is able to outwit any number of host immune defenses that it encounters during infection. However, as Nolan, James and Mallal discuss in their Perspective, there is increasing evidence that small pockets of individuals are relatively protected against HIV infection, and also experience less aggressive HIV disease progression, due to a fortuitous genetic barrier. The Perspective authors discuss the finding that a low copy number of the gene encoding CCL3L1, a ligand for CCR5 (the coreceptor that HIV must bind to for invasion of human T cells to proceed), can markedly alter HIV disease outcomes. The authors discuss the need to take into account genetic barriers like the CCR5-CCL3L1 network when developing vaccines against HIV.


D. Nolan, I. James, and S. Mallal, HIV: Experiencing the Pressures of Modern Life. Science 307, 1422-1424 (2005).

Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-Specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection
U. Malhotra, F. Li, J. Nolin, M. Allison, H. Zhao, J. I. Mullins, S. Self, and M. J. McElrath
J. Virol. 81, 5225-5237 (15 May 2007)

Unusually High Frequency MHC Class I Alleles in Mauritian Origin Cynomolgus Macaques
K. C. Krebs, Z. Jin, R. Rudersdorf, A. L. Hughes, and D. H. O'Connor
J. Immunol. 175, 5230-5239 (15 October 2005)

Commentary: Sifting through the maze of viral and host diversity and HIV/AIDS clinical progression
V. Miller, Z. Jin, R. Rudersdorf, A. L. Hughes, and D. H. O'Connor
Int J Epidemiol 34, 584-585 (1 June 2005)

How HIV Performs Under Stress
Z. Jin, R. Rudersdorf, A. L. Hughes, and D. H. O'Connor
AIDS Clin Care 2005, 7-7 (13 April 2005)

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