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Target Cell-Dependent Normalization of Transmitter Release at Neocortical Synapses

Science, 6 May 2005
Vol. 308, Issue 5723, p. 863-866
DOI: 10.1126/science.1100815

Target Cell-Dependent Normalization of Transmitter Release at Neocortical Synapses

  1. Helmut J. Koester1,2,*,,
  2. Daniel Johnston2,*
  1. 1 Abteilung Zellphysiologie, Max-Planck-Institut für Medizinische Forschung, Jahnstraße 29, D-69120 Heidelberg, Germany.
  2. 2 Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
  1. To whom correspondence should be addressed. E-mail: HKoester{at}mail.utexas.edu
  • Published online 17 March 2005;

  • Include this information when citing this paper.

  • * Present address: Center for Learning and Memory, University of Texas at Austin, Austin, TX 78712, USA.

Abstract

The efficacy and short-term modification of neocortical synaptic connections vary with the type of target neuron. We investigated presynaptic Ca2+ and release probability at single synaptic contacts between pairs of neurons in layer 2/3 of the rat neocortex. The amplitude of Ca2+ signals in boutons of pyramids contacting bitufted or multipolar interneurons or other pyramids was dependent on the target cell type. Optical quantal analysis at single synaptic contacts suggested that release probabilities are also target cell-specific. Both the Ca2+ signal and the release probability of different boutons of a pyramid contacting the same target cell varied little. We propose that the mechanisms that regulate the functional properties of boutons of a pyramid normalize the presynaptic Ca2+ influx and release probability for all those boutons that innervate the same target cell.

    • Received for publication 27 May 2004.
    • Accepted for publication 10 February 2005.

    Citation:

    H. J. Koester and D. Johnston, Target Cell-Dependent Normalization of Transmitter Release at Neocortical Synapses. Science 308, 863-866 (2005).

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