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Separation of Conjoined Hormones Yields Appetite Rivals

Science, 11 November 2005
Vol. 310, Issue 5750, p. 985-986
DOI: 10.1126/science.1121214

Separation of Conjoined Hormones Yields Appetite Rivals

  1. Ruben Nogueiras,
  2. Matthias Tschöp*
  1. The authors are in the Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, USA, and the Department of Pharmacology, German Institute of Human Nutrition, 14558 Nuthetal, Germany. E-mail: tschoemh{at}


In their Perspective, Nogueiras and Tschöp discuss the study of Zhang et al. that has identified obestatin, a new hormone regulator of energy balance. Obestatin suppresses food intake, body weight gain, and gastrointestinal motility in rodents. The paradox is that obestatin is derived from a precursor peptide that also yields ghrelin, a hormone that increases appetite and body weight.


R. Nogueiras and M. Tschöp, Separation of Conjoined Hormones Yields Appetite Rivals. Science 310, 985-986 (2005).

Hypothalamic Ceramide Levels Regulated by CPT1C Mediate the Orexigenic Effect of Ghrelin
S. Ramirez, L. Martins, J. Jacas, P. Carrasco, M. Pozo, J. Clotet, D. Serra, F. G. Hegardt, C. Dieguez, M. Lopez et al.
Diabetes 62, 2329-2337 (1 July 2013)

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