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Assistance of Microbial Glycolipid Antigen Processing by CD1e

Science, 25 November 2005
Vol. 310, Issue 5752, p. 1321-1324
DOI: 10.1126/science.1115301

Assistance of Microbial Glycolipid Antigen Processing by CD1e

  1. Henri de la Salle1,*,
  2. Sabrina Mariotti2,*,
  3. Catherine Angenieux1,*,
  4. Martine Gilleron3,*,
  5. Luis-Fernando Garcia-Alles4,
  6. Dag Malm5,
  7. Thomas Berg6,
  8. Samantha Paoletti2,
  9. Blandine Maître1,
  10. Lionel Mourey4,
  11. Jean Salamero7,
  12. Jean Pierre Cazenave8,
  13. Daniel Hanau1,
  14. Lucia Mori2,
  15. Germain Puzo3,,
  16. Gennaro De Libero2,
  1. 1 INSERM, U725, Etablissement Francais du Sang-Alsace, F-67065 Strasbourg, France.
  2. 2 Experimental Immunology, Department of Research, Basel University Hospital, CH-4031 Basel, Switzerland.
  3. 3 CNRS, UMR 5089, Immunochimie et Glycoconjugués Mycobacteriens, Institut de Pharmacologie et de Biologie Structurale, F-31077 Toulouse Cedex, France.
  4. 4 Biophysique Structurale, Département Mécanismes Moléculaires des Infections Mycobactériennes, Institut de Pharmacologie et de Biologie Structurale, F-31077 Toulouse Cedex, France.
  5. 5 Department of Medicine, University Hospital of Northern Norway, N-9038 Tromsø, Norway.
  6. 6 Department of Pathology, University Hospital of Northern Norway, N-9038 Tromsø, Norway.
  7. 7 CNRS, UMR 144, Institut Curie, F-75005 Paris, France.
  8. 8 INSERM, U311, Etablissement Francais du Sang-Alsace, F-67065 Strasbourg, France.
  1. To whom correspondence should be addressed. E-mail: gennaro.delibero{at}unibas.ch (G.D.L.); germain.puzo{at}ipbs.fr (G.P.)
  • * These authors contributed equally to this work.

Abstract

Complexes between CD1 molecules and self or microbial glycolipids represent important immunogenic ligands for specific subsets of T cells. However, the function of one of the CD1 family members, CD1e, has yet to be determined. Here, we show that the mycobacterial antigens hexamannosylated phosphatidyl-myo-inositols (PIM6) stimulate CD1b-restricted T cells only after partial digestion of the oligomannose moiety by lysosomal α-mannosidase and that soluble CD1e is required for this processing. Furthermore, recombinant CD1e was able to bind glycolipids and assist in the digestion of PIM6. We propose that, through this form of glycolipid editing, CD1e helps expand the repertoire of glycolipidic T cell antigens to optimize antimicrobial immune responses.

    • Received for publication 25 May 2005.
    • Accepted for publication 27 October 2005.

    Citation:

    H. de la Salle, S. Mariotti, C. Angenieux, M. Gilleron, L.-F. Garcia-Alles, D. Malm, T. Berg, S. Paoletti, B. Maître, L. Mourey, J. Salamero, J. P. Cazenave, D. Hanau, L. Mori, G. Puzo, and G. De Libero, Assistance of Microbial Glycolipid Antigen Processing by CD1e. Science 310, 1321-1324 (2005).

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