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A Plant miRNA Contributes to Antibacterial Resistance by Repressing Auxin Signaling

Science, 21 April 2006
Vol. 312, Issue 5772, p. 436-439
DOI: 10.1126/science.1126088

A Plant miRNA Contributes to Antibacterial Resistance by Repressing Auxin Signaling

  1. Lionel Navarro1,2,
  2. Patrice Dunoyer2,
  3. Florence Jay2,
  4. Benedict Arnold3,
  5. Nihal Dharmasiri4,
  6. Mark Estelle4,
  7. Olivier Voinnet2,*,,
  8. Jonathan D. G. Jones1,*,
  1. 1 The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK.
  2. 2 Institut de Biologie Molèculaire des Plantes du Centre National de la Recherche Scientifique, 67084 Strasbourg Cedex, France.
  3. 3 John Innes Centre, Colney Lane, Norwich NR4 7UH, UK.
  4. 4 Department of Biology, Indiana University, Bloomington, IN 47405, USA.
  1. To whom correspondence should be addressed. E-mail: jonathan.jones{at} (J.D.G.J.); olivier.voinnet{at} (O.V.)
  • * These authors contributed equally to this work.


Plants and animals activate defenses after perceiving pathogen-associated molecular patterns (PAMPs) such as bacterial flagellin. In Arabidopsis, perception of flagellin increases resistance to the bacterium Pseudomonas syringae, although the molecular mechanisms involved remain elusive. Here, we show that a flagellin-derived peptide induces a plant microRNA (miRNA) that negatively regulates messenger RNAs for the F-box auxin receptors TIR1, AFB2, and AFB3. Repression of auxin signaling restricts P. syringae growth, implicating auxin in disease susceptibility and miRNA-mediated suppression of auxin signaling in resistance.

    • Received for publication 10 February 2006.
    • Accepted for publication 23 March 2006.


    L. Navarro, P. Dunoyer, F. Jay, B. Arnold, N. Dharmasiri, M. Estelle, O. Voinnet, and J. D. Jones, A Plant miRNA Contributes to Antibacterial Resistance by Repressing Auxin Signaling. Science 312, 436-439 (2006).

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