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Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α

Science, 28 April 2006
Vol. 312, Issue 5773, p. 572-576
DOI: 10.1126/science.1123480

Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α

  1. Claudio Hetz1,2,*,
  2. Paula Bernasconi1,
  3. Jill Fisher1,
  4. Ann-Hwee Lee2,
  5. Michael C. Bassik1,
  6. Bruno Antonsson4,
  7. Gabriel S. Brandt5,
  8. Neal N. Iwakoshi2,
  9. Anna Schinzel1,
  10. Laurie H. Glimcher2,3,*,
  11. Stanley J. Korsmeyer1,
  1. 1 Howard Hughes Medical Institute, Dana–Farber Cancer Institute, and Harvard Medical School, Boston, MA 02115, USA.
  2. 2 Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
  3. 3 Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
  4. 4 Serono Pharmaceutical Research Institute, 14 Chemin des Aulx, 1228 Plan les Ouates, Switzerland.
  5. 5 Departments of Biochemistry and Chemistry, Rosenstiel Center, Brandeis University, Waltham, MA 02454, USA.
  1. * To whom correspondence should be addressed. E-mail: lglimche{at}hsph.harvard.edu (L.H.G.); chetz{at}hsph.harvard.edu. (C.H.)
  • Deceased.

Abstract

Accumulation of misfolded protein in the endoplasmic reticulum (ER) triggers an adaptive stress response—termed the unfolded protein response (UPR)—mediated by the ER transmembrane protein kinase and endoribonuclease inositol-requiring enzyme–1α (IRE1α). We investigated UPR signaling events in mice in the absence of the proapoptotic BCL-2 family members BAX and BAK [double knockout (DKO)]. DKO mice responded abnormally to tunicamycin-induced ER stress in the liver, with extensive tissue damage and decreased expression of the IRE1 substrate X-box–binding protein 1 and its target genes. ER-stressed DKO cells showed deficient IRE1α signaling. BAX and BAK formed a protein complex with the cytosolic domain of IRE1α that was essential for IRE1α activation. Thus, BAX and BAK function at the ER membrane to activate IRE1α signaling and to provide a physical link between members of the core apoptotic pathway and the UPR.

    • Received for publication 6 December 2005.
    • Accepted for publication 27 March 2006.

    Citation:

    C. Hetz, P. Bernasconi, J. Fisher, A.-H. Lee, M. C. Bassik, B. Antonsson, G. S. Brandt, N. N. Iwakoshi, A. Schinzel, L. H. Glimcher, and S. J. Korsmeyer, Proapoptotic BAX and BAK Modulate the Unfolded Protein Response by a Direct Interaction with IRE1α. Science 312, 572-576 (2006).

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